In a nutshell This study compared the effectiveness and safety of tofacitinib (Xeljanz) and baricitinib (Olumiant) in patients with rheumatoid arthritis in a real-world setting. The data showed that tofacitinib and baricitinib had similar effectiveness and safety but clinical responses may depend on previous use of anti-rheumatic drugs. Some...
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In a nutshell This study investigated the neutrophil-to-lymphocyte ratio (NLR) as an indicator of infection in patients with rheumatoid arthritis (RA) treated with tocilizumab (Actemra). They found that the NLR is an accurate indicator of infection in these patients. Some background Rheumatoid arthritis (RA) is a chronic condition. It...
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In a nutshell This study investigated the long-term safety of rituximab (Rituxan) in patients with rheumatoid arthritis (RA). They found that the rate of infections did not increase with prolonged rituximab treatment. Some background Treating rheumatoid arthritis (RA) involves taking medication to reduce symptoms. RA is caused by inflammation and is...
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In a nutshell This study investigated the effects of tocilizumab (Actemra) treatment every 6 weeks in patients with rheumatoid arthritis. They found that tocilizumab every 6 weeks maintains low disease activity for most patients. Some background Rheumatoid arthritis (RA) is a chronic (long-term) illness. The aim of RA treatment is to...
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In a nutshell This study investigated if there are disease features that can predict if a patient with rheumatoid arthritis will respond well to methotrexate treatment. They found that higher disease activity at early stages of treatment predicted a poor treatment response in these patients. Some background Treatment of rheumatoid arthritis (RA)...
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In a nutshell This study investigated whether upadacitinib is a safe and effective treatment for unresponsive patients with rheumatoid arthritis (RA). They concluded that upadacitinib improved RA symptoms in combination with csDMARDs and was well tolerated. Some background ne type of medication used to treat rheumatoid arthritis...
Read MoreIn a nutshell This study examined the features of long-term disease remission in patients with rheumatoid arthritis (RA) on reduced treatment. The study concluded that disease activity, synovitis, rheumatoid factor and a history of smoking are associated with treatment failure. Some background Biological (b)DMARDs (disease-modifying...
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In a nutshell This study compared sarilumab and adalimumab for the treatment of rheumatoid arthritis (RA). They found that sarilumab–treated patients reported greater improvements in overall health and disability, quality of life and pain scores. Some background Treatment of rheumatoid arthritis (RA) involves medications to reduce...
Read MoreIn a nutshell This study investigated adverse events associated with glucocorticoid medications in patients with rheumatoid arthritis. The study found that patients with RA have an increased incidence of adverse events associated with the use of glucocorticoids. Some background Treatment of rheumatoid arthritis (RA) involves taking...
Read MoreIn a nutshell This study investigated if non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of heart attack or stroke in patients with rheumatoid arthritis (RA). They found that non-selective NSAIDs were associated with an increased risk of both stroke and heart attack in RA patients. Some background One type of medication used to...
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In a nutshell This study investigated the risk of skin cancer in patients taking disease-modifying drugs (DMARDs) and corticosteroids to treat rheumatoid arthritis (RA). They concluded that certain DMARDs and corticosteroids are associated with an increased risk of non-melanoma skin cancer. Some background Rheumatoid arthritis (RA) is a...
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In a nutshell This study investigated the safety of etoricoxib for the treatment of rheumatoid arthritis and osteoarthritis. They found that etoricoxib did not increase the risk of gastrointestinal adverse events. Some background Rheumatoid arthritis (RA) and osteoarthritis (OA) are conditions that cause painful swelling in the joins and bones of...
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