In a nutshell This phase 3 clinical trial assessed the efficacy and safety of radium-223 dichloride or radium-223 (Xofigo) in patients with prostate cancer that has spread to the bone. Some background Testosterone, the main male sex hormone, promotes the growth of prostate cancer. A treatment option for prostate cancer patients is castration...
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In a nutshell This study evaluated the frequency and severity of nerve damage (neuropathy) caused by chemotherapy in patients with colorectal cancer. Additionally, researchers evaluated the impact this side effect has on patients’ quality of life. Some background Neuropathy is the damage of nerves caused either by disease or by treatments...
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In a nutshell This review evaluated the role of pertuzumab (perjeta) as treatment for metastatic HER2+ breast cancer. Some background Relapse rates (the incidence of cancer return) in breast cancer have declined in recent years due to new treatments which specifically target the type of breast cancer a patient has. Permutuzab, for example, is...
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In a nutshell In this article, researchers investigated the adverse effects of zoledronic acid (Zometa) in breast cancer patients. Specifically, they examined the occurrence of osteonecrosis of the jaw (ONJ) and other oral (mouth) complications. Some background Zoledronic acid (zoledronate) is a drug commonly used to treat osteoporosis (loss...
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In a nutshell This article evaluated the effects of chemotherapy after the surgical removal of liver and lung metastases on survival in patients with colorectal cancer (CRC). Some background Metastatic CRC is cancer that has spread from the large intestine to distant organs or tissues in the body. The parts of the body mainly affected by...
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In a nutshell This study compared the effect of two chemotherapy drugs used in the treatment of metastatic prostate cancer. Survival rates and pain relief were compared with cabazitaxel (jevtana) or mitoxantrone (novantrone) therapy. Some background Testosterone, the main male sex hormone, facilitates in the growth of...
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In a nutshell This article looked at the pathological features of prostate cancer to identify those patients who would benefit the most from adjuvant radiotherapy after radical prostatectomy. Some background One option for patients with prostate cancer is surgery to remove the cancer along with the entire prostate gland and some healthy tissues...
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A total of 173 patients with metastatic (a cancer that has spread to other organs) TNBC were involved in the study. 115 patients were assigned to receive cisplatin and cetuximab together, while 58 patients received cisplatin alone. 20% of the patients treated with cisplatin plus cetuximab showed some response to treatment, compared to only...
Read MoreIn a nutshell This study compared the effects of different therapies in the treatment of high-risk prostate cancer. Failure of treatment and mortality rates were compared between the use of external beam radiotherapy (EBRT) and combined modality radiotherapy (CMRT). The effect of adding androgen deprivation therapy (ADT) to the treatment plan...
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In a nutshell This study investigated whether the PD-1 antibody lambrolizumab improves the condition of patients with advanced melanoma. Some background The programmed death 1 (PD-1) receptor is a structure normally found on cells of the immune system, and when activated inhibits their activity. Some cancer cells can activate the PD-1 receptor and...
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In a nutshell This study evaluated the effect of abiraterone acetate plus prednisone on pain and skeletal-related symptoms in patients with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel chemotherapy. Some background Prostate cancer growth is fueled by testosterone, the main male sex hormone. Treatment options include...
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In a nutshell This article looked at the use of a platinum based chemotherapy (cisplatin) to a non-platinum based chemotherapy for patients with triple negative breast cancer. Some background Most breast cancers have on their surface some proteins called receptors that help the breast cancers grow. These can be hormone receptors (estrogen or...
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