In a nutshell This study compared the effect of radiation therapy versus radical prostatectomy (surgical removal of the prostate gland and some healthy tissue around it) on survival rates in patients with prostate cancer (PCa) who had metastasis (cancer spread to distant organs and tissues of the body) after treatment. Some background Radiation...
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In a nutshell This review discusses current therapy as well as ongoing advances in the treatment of non small-cell lung cancer. Some background Many advances have been made in recent years in the treatment of non small-cell lung cancer (NSCLC). New technologies used in radiation therapy are allowing for a more targeted and precise delivery of...
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In a nutshell This trial investigated the impact of lifestyle changes in diet and exercise on the quality of life (QoL) of advanced prostate cancer (PC) patients. Some background PC can affect patients' QoL as a direct result of the disease itself and as side effects from treatments. Erectile dysfunction (problems obtaining or...
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In a nutshell This article reviewed the development and use of biological therapies in the treatment of advanced melanoma, including possible future directions. Some background Targeted molecular therapies and immunotherapies are two commonly used therapeutic approaches for the treatment of advanced melanoma. Targeted molecular therapies...
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In a nutshell This study investigated the benefits of chemotherapy to treat inoperable (that cannot be removed through surgery) metastases from colorectal cancer (CRC). Some background When CRC is discovered early, the preferred method of treatment is surgery to remove the cancer along with some surrounding healthy tissue. Chemotherapy is often...
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In a nutshell This analysis of several case studies evaluated whether removal of primary tumor in stage IV breast cancer helps improve overall survival. Some background In stage IV (metastatic) breast cancer, the cancer spreads beyond the breast and nearby lymph nodes, to other organs and tissues of the body, such as the lungs, liver, bones or...
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In a nutshell This review examined the combination of several chemotherapy agents with bevacizumab (Avastin) in the treatment of patients with advanced colorectal cancer. Some background Advanced cases of colorectal cancer (CRC) are generally treated with chemotherapy in addition to surgery. A combination of three drugs, 5-fluorouracil,...
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In a nutshell This phase III clinical trial compared the efficacy of pemetrexed (Alimta) chemotherapy alone, versus the combination of carboplatin plus pemetrexed, as first treatment for patients with advanced non small-cell lung cancer (NSCLC) Some background NSCLC is the most common type of lung cancer and often requires chemotherapy....
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In a nutshell This study presented the results of targeted therapies in patients treated for metastatic melanoma. Some background In recent years, a growing understanding of the molecular mechanisms leading to the development of cancer has uncovered several genetic mutations associated with the formation of melanoma. New therapies which...
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In a nutshell This study examined the benefits of nanoparticle albumin-bound paclitaxel in combination with bevacizumab as first-line treatment (the first treatment of choice) for metastatic breast cancer patients. Some background Paclitaxel is one of several chemotherapy drugs used to treat cancer. However, treatment is often associated with...
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In a nutshell This study compared two treatment strategies for advanced non-small cell lung cancer: platinum analog chemotherapy plus the drug bevacizumab (avastin) versus platinum analog chemotherapy alone. Some background Treatment for advanced non-small cell lung cancer typically involves treatment with chemotherapy. Standard chemotherapy...
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In a nutshell This study analyzed the efficacy and safety of ipilimumab (Yervoy) exposure in patients with advanced melanoma. It assessed the relationship between patient response and drug dosage (amount of drug administered) through the minimum steady-state concentration or Cminss (the lowest concentration that the drug reaches before the next...
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