In a nutshell This analysis evaluated the efficacy and safety of ipilimumab in treatment of patients with metastatic uveal melanoma. Some background Ocular melanoma or uveal melanoma is a cancer of the eye. Tumors arise from the pigment cells (melanocytes) that reside within the uvea giving color to the eye. Once metastasis...
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In a nutshell This study investigated the association between survival and beta-blocker use in colorectal cancer. Some background Colorectal cancer is one of the most common malignant diseases worldwide. Despite recent advances in treatments such surgery, chemotherapy and radiotherapy, survival rates among advanced colorectal cancer patients...
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In a nutshell This study examined the use of electrochemotherapy in patients with skin (cutaneous) metastases from melanoma. Some background Melanoma recurs (comes back) in 80% of patients within 5 years, often at sites distant to the original tumor. Melanoma cells can be spread through both the bloodstream and the lymphatic system, and it often...
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In a nutshell This study analyzed the efficacy and safety of a combination of carboplatin and S-1 in the treatment of advanced non-small cell lung cancer (NSCLC). Some background NSCLC accounts for 85% of lung cancers, and appears in two distinct histological subtypes; squamous cell carcinoma and non-squamous cell carcinoma....
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In a nutshell This study evaluated whether past surgery could be used to predict response to bevacizumab (Avastin) treatment among metastatic cancer patients. Some background Combined treatment with bevacizumab and chemotherapy is the standard of care for the treatment of metastatic (wide spread) colorectal cancer. Bevacizumab acts by inhibiting...
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In a nutshell This study examined the most accurate predictor of survival in patients with metastatic melanoma being treated with bevacizumab (Avastin). Some background Since melanomas are highly dependent on the formation of new blood vessels, bevacizumab (Avastin), a drug which blocks new blood vessel formation, is often used in their treatment....
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In a nutshell This study estimated survival gain with the addition of aflibercept (Zaltrap) to standard chemotherapy among patients with metastatic colorectal cancer. Some background A combination chemotherapy regimen referred to as FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) is considered the standard of care in the treatment of...
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In a nutshell This study evaluated the impact of breast cancer subtypes on disease prognosis in patients with metastatic breast cancer (cancer that has spread outside the breasts to the other parts of the body). Some background Breast cancer is classified into different subtypes depending on the presence or absence of certain receptors (proteins...
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In a nutshell This review analyzed the efficacy and safety of vandetanib (Caprelsa) in combination with chemotherapy for the treatment of advanced non-small cell lung cancer. Some background Chemotherapy is often the standard of treatment for advanced non-small cell lung cancer (NSCLC). However, response rates to treatments, as well as survival,...
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In a nutshell This study examined the effectiveness and safety of a new chemotherapy combination including oxaliplatin, irinotecan, and S-1 for the treatment of metastatic colorectal cancer. Some background For several years, standard chemotherapy for metastatic colorectal cancer (a cancer which has spread to other organs) included a combination...
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In a nutshell This study evaluated the safety and efficacy of chemotherapy (CT) given concurrently with 3-dimensional conformal radiotherapy (3D-CRT) for the treatment of patients with metastatic non-small cell lung cancer or mNSCLC (lung cancer that has spread to distant organs of the body). Some background Chemotherapy (CT) uses drugs that...
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In a nutshell This study investigated if the amount of blood lost during surgery to remove metastatic tumors (cancer spread to distant organs of the body) on the liver from primary colorectal cancer (CRC) could be used as an indicator of long term survival and tumor recurrence (return of the cancer). Some background The liver is a common site for...
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