In a nutshell The authors aimed to determine the effect of enzalutamide on quality of life in patients with hormone-resistant prostate cancer after chemotherapy. Some background Hormone therapy is a common treatment used in prostate cancer. It targets the male sex hormones active in prostate cancer, such as testosterone. Enzalutamide...
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In a nutshell The authors aimed to evaluate patients suffering from metastatic prostate cancer symptoms and to determine their effect on disease outcome. Some background Metastatic prostate cancer is cancer that has spread out from the initial tumor site, into other parts of the body. This type of cancer can cause a number of undesirable symptoms...
Read MoreIn a nutshell The authors aimed to determine the effects of taxanes when treating prostate cancer patients with hormone-resistant cancer. Some background Hormone therapy is a common prostate cancer treatment. It targets the male sex hormones active in prostate cancer, such as testosterone. Some patients may become hormone-resistant....
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In a nutshell This study examined whether the protein HER3 is increased in colorectal tumors and in colorectal cancer liver metastases (cancer that has spread from the colon or rectum to the liver). Some background To improve colorectal cancer patients’ outcomes, anticancer treatments that target specific proteins are needed. High...
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In a nutshell The objective of this study was to evaluate the safety and effectiveness of nivolumab (Opdivo) as secondary treatment in advanced melanoma. Some background In the advanced stage of melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. BRAF inhibitors and immunotherapy are the standard treatments for...
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In a nutshell The authors aimed to evaluate survival benefits of pembrolizumab (Keytruda) compared to ipilimumab (Yervoy) in advanced melanoma. Some background In the advanced stage of melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. One of the standard treatments for advanced melanoma is immunotherapy that uses...
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In a nutshell The authors assessed the safety and efficacy of ramucirumab (Cyramza) for patients with metastatic colorectal cancer (cancer that has spread from the colon or rectum to distant sites) that has progressed despite treatment. Some background Ramucirumab has recently been approved for the treatment of metastatic colorectal cancer....
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In a nutshell This study assessed whether vitamin K1 creams can reduce the risk of skin rashes in patients taking cetuximab (Erbitux) for colorectal cancer. Some background The epidermal growth factor receptor (EGFR) protein is involved in cancer growth. Cetuximab is a treatment that blocks EGFR, slowing cancer growth. It is an effective...
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In a nutshell The authors assessed the safety and efficacy of two treatment combinations for colorectal cancer patients who have liver invasion but who are not eligible for surgery. Some background For patients with colorectal cancer the cancer is most likely to invade the liver if it spreads. Surgery is the best treatment option if the cancer has...
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In a nutshell This paper studied factors that could predict outcome in patients with human epidermal growth factor receptor 2 (HER2) breast cancer that has spread to the brain. Some background HER2 positive breast cancer refers to breast cancer in which there are high levels of the protein, HER2, on cancer cells. Trasutuzumab...
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In a nutshell This study examined the safety and efficacy of bevacizumab (Avastin) for treating elderly patients with metastatic colorectal cancer (cancer that has spread from the colon or rectum to distant sites). Some background Bevacizumab is an anti-cancer drug that blocks the formation of new blood vessels needed for the cancer to grow and...
Read MoreIn a nutshell The authors aimed to determine the impact of docetaxel on patient quality of life. Some background Metastatic cancer is cancer that has spread around the body from the primary tumor site. Docetaxel (Taxotere, Docecad) is a chemotherapy drug used to treat lung, prostate, breast, stomach and head/neck cancer by preventing cancer...
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