In a nutshell The authors aimed to determine whether testing circulating tumor cells for the presence of human epidermal growth factor receptor 2 (HER2) could aid in determining treatment options. Some background Circulating tumor cells (CTC’s) are cells from a primary tumor that have migrated into the blood stream. Their presence is...
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In a nutshell The authors analyzed the role of certain genes in predicting survival in melanoma patients treated with tremelimumab (CP-675,206). Some background In advanced melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. Immunotherapy is an effective treatment for advanced melanoma. It uses the...
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In a nutshell The authors determined the significance of prostate specific antigen (PSA) levels in determining survival in prostate cancer patients with bone tumors after hormone therapy Some background Hormone therapy is a common treatment for prostate cancer. It targets the male sex hormones active in prostate cancer, such as testosterone....
Read MoreIn a nutshell The authors determined the association between beta-blockers and prostate cancer-specific mortality (patients who died from prostate cancer following treatment) in patients with high-risk (stage IV) or metastatic (cancer spread out from prostate) cancer. Some background Hormone therapy is a common treatment used in prostate...
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In a nutshell The authors determined the effect of radiotherapy as an additional treatment, in patients with node-positive prostate cancer. Some background Radiotherapy is a common treatment used in prostate cancer. It involves directing a beam of radiation at the tumor site to kill cancer cells with minimal damage to...
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In a nutshell The authors compared nivolumab (Opdivo) in combination with ipilimumab (Yervoy) to ipilimumab alone in the treatment of advanced melanoma. Some background In the advanced stages of melanoma (stage III/IV), cancer spreads from the skin to other parts of the body. In many melanoma...
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In a nutshell The authors reviewed the biology as well as current and future treatment options for eye melanoma. Some background Uveal melanoma is a rare cancer (melanoma) of the eye. It involves three parts of the eye (iris, ciliary body and choroid) known together as the uvea. Eye melanoma is associated with a high risk...
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In a nutshell This study looked at Asian patients with non-small cell lung cancer (NSCLC) and compared the use of two drug regimens to see which was better. Some background Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Some patients with NSCLC have a genetic mutation in a specific gene, the epidermal growth factor...
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In a nutshell The authors reviewed the benefits and safety of ado–trastuzumab emtansine (Kadcyla), a treatment for metastatic breast cancer (cancer that has spread to other areas of the body). Some background Human epidermal growth factor receptor 2 positive (HER2) breast cancer depends on HER2 for growth. Treatments that target the HER2...
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In a nutshell The authors analyzed the effectiveness and safety of retreatment with ipilimumab (Yervoy) in patients with advanced melanoma. Some background The survival rate in advanced melanoma is poor. Ipilimumab, an immunotherapy (treatment that uses the body’s own immune system to fight cancer), is an...
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In a nutshell The authors aimed to evaluate a series of treatments used for advanced breast cancer; this was a review of chemotherapy drugs such as paclitaxel (Taxol), doxetaxel (Taxotere) and nab-paclitaxel (Abraxane). Some background Taxanes are a group of chemotherapy drugs used commonly in locally advanced (cancer has spread into nearby...
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In a nutshell The authors examined the safety of ipilimumab (Yervoy) and the associated skin-related adverse events in the treatment of melanoma. Some background In advanced melanoma, cancer spreads from deep within the skin to other parts of the body. Ipilimumab, an immunotherapy (treatment that uses body’s own...
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