In a nutshell This study examined the use of a type of targeted therapy called immune checkpoint inhibitors to treat advanced non-small-cell lung cancer (NSCLC). The authors concluded that for patients who had a genetic mutation (change) called KRAS, ICIs were more effective than chemotherapy. They suggest that the presence of KRAS mutations could...
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In a nutshell This meta-analysis looks at the safety and effectiveness of a new type of treatment called immune checkpoint inhibitors (ICIs). The authors concluded that ICIs are safe and effective treatment for patients with advanced non-small-cell lung cancer (NSCLC). Some background The emergence of targeted therapy has been beneficial...
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In a nutshell This study investigated the safety and effectiveness of capecitabine (Xeloda) as treatment for advanced colorectal cancer in patients 75 or more years old. Researchers suggested that this drug was effective in patients aged 75 or older with colorectal cancer, with manageable side effects. Some background Chemotherapy has...
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In a nutshell The authors aimed to determine the benefit of abiraterone acetate (Zytiga) plus prednisone (Deltasone) with hormone therapy in men with newly diagnosed, advanced prostate cancer. The authors concluded that adding abiraterone acetate plus prednisone to hormone therapy significantly increased overall survival and progression-free survival...
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In a nutshell This report aimed to develop recommendations for endocrine therapy in women with hormone receptor-positive metastatic breast cancer. Some background Endocrine therapy, also known as hormone therapy (HT) is used to treat hormone receptor (HR) positive metastatic breast cancer (MBC). HR positive MBC depends on the hormones estrogen or...
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In a nutshell The authors aimed to determine the use of pre-treatment bone scan index (BSI) as a prognostic (predictive) factor in hormone-naïve men with prostate cancer who have bone tumors. The authors concluded that pre-treatment BSI and patients age were independent prognostic factors for men with hormone-naïve prostate cancer with bone...
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In a nutshell This study looked at whether smoking status could be used to predict treatment success for patients with advanced non-small-cell lung cancer (NSCLC). The authors concluded that immunotherapy could be beneficial to patients with a history of smoking. Some background Immunotherapy is a type of cancer treatment that activates the immune...
Read MoreIn a nutshell The authors aimed to determine the effectiveness of apalutamide before or after treatment with abiraterone acetate (Zytiga) and prednisone (Deltasone) in men with advanced, hormone-resistant prostate cancer. The authors concluded that apalutamide was a safe treatment option and demonstrated effectiveness against advanced,...
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In a nutshell The aim of this phase 2 trial is to compare the effectiveness of the combined treatment with chemotherapy, avelumab (Bavencio) and the vaccine Ad-CEA in patients with metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will recruit in Maryland,...
Read MoreIn a nutshell The authors aimed to compare outcomes after local therapy versus no local therapy in men with advanced prostate cancer (cancer that has spread outside the prostate gland). The authors concluded that local therapy resulted in better outcomes when compared to no local therapy. They also concluded that in patients who received local...
Read MoreIn a nutshell The aim of this trial is to determine the effectiveness of a combination of the chemotherapies docetaxel (Taxotere) and carboplatin (Paraplatin) in advanced (spread beyond the prostate) prostate cancer. The main outcome to be measured is the number of patients who experience a decrease of 50% in prostate specific...
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In a nutshell This study aimed to investigate the association between beta blocker use and outcomes in HER2 negative breast cancer (BC) patients. This study concluded that beta blocker use leads to improved progression free survival in BC patients. Some background Beta blockers are therapies used to treat various heart related conditions....
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