In a nutshell This phase 1 trial is examining the safety and effectiveness of a new type of immunotherapy. The treatment involves genetically enhancing patients’ own immune cells to better fight advanced non-small-cell lung cancer (NSCLC) or head and neck cancer. The main outcome to be measured will be the highest safe dose of the treatment. This...
Read MoreCurrent stage -Stage IV Posts on Medivizor
Looking for men with castration-resistant prostate cancer to test ipatasertib plus abiraterone/prednisone
In a nutshell The aim of this study is to determine the effectiveness and safety of ipatasertib (GDC-0068) in combination with abiraterone (Zytiga) and prednisone/prednisolone (Deltasone) in men with metastatic castration-resistant prostate cancer. The main outcome to be measured is time to disease progression. The details Metastatic prostate...
Read MoreLooking for men with metastatic castration-resistant prostate cancer to test rucaparib
In a nutshell The aim of this trial is to determine how patients with advanced, hormone-resistant prostate cancer with evidence of a homologous recombination gene deficiency respond to rucaparib (Rubraca) treatment. The main outcome to be measured is the response to treatment, and changes to prostate-specific antigen levels (a protein present in...
Read MoreSide effects of targeted therapies to treat metastatic colorectal cancer
In a nutshell This study investigated the negative side effects of targeted therapy to treat elderly and younger metastatic (spread to other parts of the body) colorectal cancer patients. Researchers suggested that side effects were different between these patients. Some background Colorectal cancer is one of the most common cancers worldwide....
Read MoreAbemaciclib increased progression-free survival for advanced breast cancer
In a nutshell This study aimed to compare abemaciclib (Verzenio) to a placebo treatment (substance with no active effect). The study concluded that it increased progression-free survival and was relatively safe to use as a first-line treatment. Some background There are several treatment options for hormone positive, HER-2 negative...
Read MoreA combination of FOLFOXIRI and targeted therapy in the treatment of advanced colorectal cancer
In a nutshell This study examined the effectiveness of FOLFOXIRI combined with targeted therapy (TT) in advanced colorectal cancer. This study concluded that FOLFOXIRI plus TT was associated with better outcomes compared to other treatment combinations. Some background Chemotherapy is used to reduce symptoms and increase survival in colorectal...
Read MorePromising News in Melanoma From ASCO 2017
Video information: As part of our coverage from the 2017 American Society of Clinical Oncology annual meeting, Dr. Ryan Sullivan from Massachusetts General Hospital Cancer Center and Harvard Medical School provides a positive update for melanoma patients. Dr. Sullivan shares positive news related to PD-1 inhibitors and other promising advancements...
Read MoreAdvances in Treating Prostate Cancer Symptoms and Complications
Video information: Have there been advances in treating advanced prostate cancer symptoms? Andrew Schorr discusses approaches for treating symptoms and complications in men with advanced prostate cancer with Dr. Philip Kantoff of Memorial Sloan Kettering Cancer Center. Watch as Dr. Kantoff explains how radiation therapy and various...
Read MoreLooking for patients with newly diagnosed symptomatic NSCLC to test durvalumab
In a nutshell This phase 2 clinical trial will test the safety and effectiveness of durvalumab as a first-line therapy for non-small cell lung cancer (NSCLC). The primary outcome will be measured by overall survival and the number of patients with adverse (negative) side effects. The details Durvalumab is an immunotherapy for metastatic tumors...
Read MoreLooking for patients with advanced non-small cell lung cancer to test the effectiveness of Poziotinib
In a nutshell This phase 2 clinical trial will test the effectiveness of poziotinib in treating locally advanced (spread to nearby tissue) or metastatic (spread to other parts of the body) non-small cell lung cancer (NSCLC) with an EGFR mutation. The primary outcome will be measured by the response rate to the treatment. This trial is being conducted...
Read MoreLooking for patients with stage 4 or recurrent non-small cell lung cancer to test the effectiveness of a combined immunotherapy with chemotherapy
In a nutshell This phase 3 clinical trial will test the effectiveness of nivolumab (Opdivo), nivolumab with ipilimumab (Yervoy), or nivolumab with platinum-based chemotherapy compared with chemotherapy in treating patients with advanced non-small cell lung cancer (NSCLC). The primary outcome will be measured by the overall survival rate and time...
Read MorePembrolizumab vs ipilimumab: which is more effective for advanced melanoma?
In a nutshell This study compared survival rates in advanced melanoma patients treated with either pembrolizumab (Keytruda) or ipilimumab (Yervoy). The study found that patients treated with pembrolizumab had a higher survival rate and fewer overall side effects. Some background...
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