In a nutshell This phase 3 trial is examining the effectiveness of a combination treatment with panitumumab (Vectibix), leucovorin and fluorouracil after chemotherapy combined with panitumumab in metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is progression-free survival (PFS; time from treatment to...
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In a nutshell This study investigated the effect of cetuximab (Erbitux) in patients with metastatic (spread to other parts of the body) colorectal cancer who did not respond to initial cetuximab treatment. Researchers suggested that this treatment may be beneficial in longer treatment durations. Some background The standard treatment for patients...
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In a nutshell This study wanted to find out if ixabepilone (Ixempra) and capecitabine (Xeloda) work for treating triple-negative breast cancer in patients with hard to treat disease compared to using capecitabine alone. The study found that adding ixabepilone to treatment resulted in longer survival without the cancer progressing. Some background...
Read MoreIn a nutshell This trial is examining the safety and effectiveness of cabazitaxel (Jevtana) with abiraterone acetate (Zytiga) compared to abiraterone acetate alone for metastatic (cancer that has spread) castration-resistant prostate cancer (cancer that is no longer responding to hormone therapy). The main outcome measured will be the...
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In a nutshell This trial is looking to compare the effectiveness of local therapy (surgery or radiotherapy) plus ipilimumab (Yervoy) and nivolumab (Opdivo) to ipilimumab and nivolumab alone in patients with metastatic (has spread) non-small cell lung cancer (NSCLC). The main outcome that will be measured is overall...
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In a nutshell This study wanted to find out which medication is better for treating HER-2 positive breast cancer, a class of medicines called anthracyclines plus trastuzmab (Herceptin) and pertuzmab (Perjeta), or carboplatin (Paraplatin) plus trastuzmab and pertuzmab. The study found that both medications worked equally as well as each other, but the...
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In a nutshell This study wanted to see if using a different BRAF inhibitor was effective in the treatment of patients with melanoma. The study found that retreating with a slightly different BRAF inhibitor worked well. Some background Around 50% of patients with melanoma that has spread have a mutation in one of their genes. This gene is...
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In a nutshell This study wanted to see how well using metronomic chemotherapy with capecitabine (Xeloda) combined with aromatase inhibitors works for patients with hormone receptor positive advanced breast cancer. The study found that this treatment works well and is safe, and therefore should be considered as a potential treatment option. Some...
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In a nutshell This study wanted to find out if the drug pembrolizumab (Keytruda) is effective in treating mucosal melanoma. The study found that pembrolizumab had some effect on mucosal melanoma, and the overall survival of patients was 11 months. Some background Mucosal melanoma is a very aggressive type of cancer, with no specific treatment. Recent...
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In a nutshell This study aimed to investigate the use of dexamethasone, instead of prednisone, used with abiraterone acetate (Zytiga) for patients with metastatic castration-resistant prostate cancer (mCRPC). This study found that prednisone to dexamethasone switch can benefit some patients with mCRPC. Some background Androgen deprivation therapy...
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In a nutshell This study compared the effectiveness of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) with other treatment options in patients with colorectal cancer (CRC) and peritoneal metastasis (PM; when cancer spreads to the abdominal lining). Researchers suggested that CRS + HIPEC brings the greatest...
Read MoreIn a nutshell This study analysed a new medication to treat advanced melanoma called SD-101. The study found that patients responded very well to injection of the medication directly into the tumor alongside a common medication called pembrolizumab (Keytruda), although this worked best in patients who had never been treated with pembrolizumab...
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