In a nutshell This study investigated the effectiveness of the combined treatment FOLFIRI with aflibercept (Zaltrap) outside of clinical trials in patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that this treatment might be a safe second line option in patients who progressed after first-line...
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In a nutshell This trial is examining the effectiveness of radical prostatectomy, in newly diagnosed advanced prostate cancer. The main outcome to be measured will be survival without the cancer worsening. This trial is recruiting in the United States. The details Androgens can cause the growth of prostate cancer cells. Antiandrogen therapy (ADT) may...
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In a nutshell This study investigated the effectiveness of a radionuclide (RN), [¹??Lu]-PSMA-617, to treat metastatic castration-resistant prostate cancer (mCRPC) that has worsened after standard treatments. They found that this treatment was safe and effective for these patients. Some background Prostate cancer (PC) affects the...
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In a nutshell This phase 2 trial will investigate the safety and effectiveness of tisotumab vedotin (TTV) for the treatment of solid tumors. The main outcome will be the response rate to treatment. This trial will take place in the United States, France, and Italy. The details Colorectal cancer (CRC) is caused by excessive cell growth...
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In a nutshell This phase 2 trial will investigate the safety and effectiveness of tisotumab vedotin (TTV) for the treatment of solid tumors. The main outcome will be the response rate to treatment. This trial will take place in the United States, France, and Italy. The details Non-small cell lung cancer (NSCLC) is caused by excessive cell growth in...
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In a nutshell This study evaluated the safety of nivolumab (Opdivo) combined with radiation therapy for patients with advanced non-small cell lung cancer (NSCLC) that has spread. This study found that radiation therapy before or after treatment with nivolumab was not associated with an increased risk of severe side effects. Some background...
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In a nutshell This study aimed to investigate the use of combined-modality radiation treatment (CRT) in the treatment of prostate cancer (PCa). This study found that CRT is an effective treatment for PCa. Some background Radiation therapy can be delivered externally such as external beam radiation therapy (EBRT), or directly into the...
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In a nutshell This article investigated the safety and effectiveness of epacadostat and pembrolizumab (Keytruda) for patients with advanced melanoma. The authors concluded that this therapy is safe and has encouraging effectiveness in these patients. Some background The immune system normally works to detect...
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In a nutshell This study evaluates the effectiveness of medication and focal radiation in the treatment of prostate cancer resistant male hormone suppression. The main outcome to be measured in this trial is the number of patients whose cancer does not grow or spread and who are alive at 18 months after treatment. This trial is taking place in Ann...
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In a nutshell This study wanted to find out which medication is better for treating lung cancer that has spread to the brain or spinal cord, crizotinib (Xalkori) or alectinib (Alecensa). The study found that alectinib worked better than crizotinib for treatment of tumors of the brain and spinal cord. Some background Alectinib and crizotinib are two...
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In a nutshell This study wanted to find out if treating breast cancer with everolimus (Afintor) and endocrine therapy is better than only treating with endocrine therapy. The study found that using everolimus in addition to endocrine therapy had a significant benefit to survival in these patients. Some background Breast cancer is classified into types...
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In a nutshell This study wanted to find out how well radiotherapy treatment works for people with stage 4 non-small cell lung cancer. The study found that overall survival was improved in patients who had radiotherapy treatment compared to those who did not. Some background There are a number of options for treatment of non-small cell lung...
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