In a nutshell This study wanted to find out if advances in the treatment of melanoma over the last 60 years have had an impact on the survival of patients. The study found that while modern drug therapy improves survival, the most effective approach is to surgically remove the tumors that have spread through the body. Some background Melanoma can be...
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In a nutshell This study wanted to find out how well patients with hormone-receptor-positive breast cancer survived when treated with ribociclib (Kisqali) added to endocrine therapy. The study found that patients treated with this treatment combination had longer survival compared to endocrine therapy alone. Some background Advanced breast cancer can...
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In a nutshell This phase 1/2 trial is examining the effectiveness of a new immunotherapy in the treatment of patients with advanced colorectal cancer (CRC). The main outcome to be measured will be tumor response to the treatment. This study is being conducted in Texas, USA. The details CRC is the third most common cancer worldwide. The 5-year...
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In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced lung cancer and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details Advanced...
Read MoreIn a nutshell This phase 2 trial is examining the effectiveness and safety of trametinib (Mekinist) in patients with metastatic castration-resistant prostate cancer (mCRPC; prostate cancer which has spread from its original place to another area in the body and keeps growing even when the amount of testosterone in the body...
Read MoreIn a nutshell This phase 2 trial is examining the effectiveness and safety of navarixin (MK-7123) in combination with pembrolizumab (Keytruda) in patients with castration-resistant prostate cancer (CRPC; cancer that progresses after hormonal therapy). The main outcome to be measured will be the objective response rate (ORR; tumor shrinkage or...
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In a nutshell This study investigated the outcomes of stage 4 colorectal cancer patients who received surgery. Researchers suggested that surgery in these patients is associated with an improved 5-year survival rate. Some background Colorectal cancer is the second leading cause of death in the US. A significant number of patients presents have stage 4...
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In a nutshell This study investigated the safety and effectiveness of palbociclib (Ibrance) in geriatric patients. They found that this treatment was well-tolerated and effective in these patients. Some background Breast cancer (BC) is one of the most common cancers. There are many subtypes of BC. The most common form is hormone...
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In a nutshell This study examined the long-term outcomes of patients with melanoma who received surgery and high-dose interferon-α (HDI). This study found that HDI treatment resulted in a decreased chance of the cancer coming back after 17 years. Some background Surgery followed by anti-cancer therapy has remained the standard of care...
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In a nutshell This article investigated the safety and effectiveness of androgen-deprivation therapy (ADT) combined with external beam radiation therapy (EBRT) for the treatment of locally advanced prostate cancer (LAPC). The authors concluded that ADT combined with EBRT is a safe and effective treatment option for these...
Read MoreIn a nutshell This article investigated the safety and effectiveness of docetaxel (Taxotere)-based chemotherapy in combination with dexamethasone (Decadron) for the treatment of castration-resistant prostate cancer (CRPC). The authors concluded that this treatment combination is a safe and effective treatment option for...
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In a nutshell This article investigated the safety and effectiveness of Lutetium-177 PSMA (LuPSMA) for the treatment of metastatic castration-resistant prostate cancer (mCRPC). The authors concluded that LuPSMA is a safe and effective treatment option for these patients. Some background mCRPC is cancer which has spread from its original site...
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