In a nutshell This phase 2 trial is examining the effectiveness and safety of trametinib (Mekinist) in patients with metastatic castration-resistant prostate cancer (mCRPC; prostate cancer which has spread from its original place to another area in the body and keeps growing even when the amount of testosterone in the body...
Read MoreCurrent stage -Stage IV Posts on Medivizor
Searching for patients with prostate cancer to test this new treatment combination
In a nutshell This phase 2 trial is examining the effectiveness and safety of navarixin (MK-7123) in combination with pembrolizumab (Keytruda) in patients with castration-resistant prostate cancer (CRPC; cancer that progresses after hormonal therapy). The main outcome to be measured will be the objective response rate (ORR; tumor shrinkage or...
Read MoreHormone deprivation and radiotherapy for locally-advanced prostate cancer.
In a nutshell This article investigated the safety and effectiveness of androgen-deprivation therapy (ADT) combined with external beam radiation therapy (EBRT) for the treatment of locally advanced prostate cancer (LAPC). The authors concluded that ADT combined with EBRT is a safe and effective treatment option for these...
Read MoreLong term outcomes of docetaxel-based chemotherapy with dexamethasone for advanced prostate cancer
In a nutshell This article investigated the safety and effectiveness of docetaxel (Taxotere)-based chemotherapy in combination with dexamethasone (Decadron) for the treatment of castration-resistant prostate cancer (CRPC). The authors concluded that this treatment combination is a safe and effective treatment option for...
Read MoreEvaluating Lu177-PSMA therapy for men with advanced prostate cancer
In a nutshell This article investigated the safety and effectiveness of Lutetium-177 PSMA (LuPSMA) for the treatment of metastatic castration-resistant prostate cancer (mCRPC). The authors concluded that LuPSMA is a safe and effective treatment option for these patients. Some background mCRPC is cancer which has spread from its original site...
Read MoreSearching for patients with metastatic prostate cancer to test this new treatment combination
In a nutshell This phase 3 trial is examining the effectiveness and safety of niraparib (Zejula) in combination with abiraterone acetate (Zytiga) and prednisone (Deltasone) vs abiraterone acetate and prednisone plus placebo for patients with metastatic prostate cancer. The main outcome to be measured will be the survival...
Read MoreLooking for men with high-risk prostate cancer features after prostate surgery to trial a type of radiation therapy
In a nutshell This trial is examining the effectiveness of radiation therapy, in treating patients with high-risk prostate cancer features after radical prostatectomy (surgery to remove the prostate gland). The main outcome to be measured will be freedom from failure. Failure is evidence that the cancer has returned. Patients will be followed up for 5...
Read MoreLooking for men with newly diagnosed advanced prostate cancer to test treatment combinations
In a nutshell This trial is examining the effectiveness of radical prostatectomy, in newly diagnosed advanced prostate cancer. The main outcome to be measured will be survival without the cancer worsening. This trial is recruiting in the United States. The details Androgens can cause the growth of prostate cancer cells. Antiandrogen therapy (ADT) may...
Read MoreEvaluating a radionuclide treatment for metastatic castration-resistant prostate cancer
In a nutshell This study investigated the effectiveness of a radionuclide (RN), [¹??Lu]-PSMA-617, to treat metastatic castration-resistant prostate cancer (mCRPC) that has worsened after standard treatments. They found that this treatment was safe and effective for these patients. Some background Prostate cancer (PC) affects the...
Read MoreCombined radiation therapy used to treat unfavorable-risk prostate cancer
In a nutshell This study aimed to investigate the use of combined-modality radiation treatment (CRT) in the treatment of prostate cancer (PCa). This study found that CRT is an effective treatment for PCa. Some background Radiation therapy can be delivered externally such as external beam radiation therapy (EBRT), or directly into the...
Read MoreLooking for men with prostate cancer, resistant to male hormone suppression, to be treated with medication and radiotherapy
In a nutshell This study evaluates the effectiveness of medication and focal radiation in the treatment of prostate cancer resistant male hormone suppression. The main outcome to be measured in this trial is the number of patients whose cancer does not grow or spread and who are alive at 18 months after treatment. This trial is taking place in Ann...
Read MoreSearching for patients with castration resistant metastatic prostate cancer to test cabazitaxel and abiraterone
In a nutshell This trial is examining the safety and effectiveness of cabazitaxel (Jevtana) with abiraterone acetate (Zytiga) compared to abiraterone acetate alone for metastatic (cancer that has spread) castration-resistant prostate cancer (cancer that is no longer responding to hormone therapy). The main outcome measured will be the...
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