In a nutshell This article investigated the safety and effectiveness of nivolumab (Opdivo) in combination with stereotactic body radiotherapy (SBRT) for patients with locally advanced melanoma unsuitable for surgery. The authors concluded that this therapy is effective with manageable side effects in these...
Read More
In a nutshell This study investigated the use of 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) to follow-up during treatment and predict the outcomes of patients with high-risk localized rectal cancer. Researchers suggested that this method can be very useful to assess the tumor before the surgery and predict response to...
Read More
In a nutshell This phase 2 trial will investigate the safety and efficacy of niraparib (Zejula) in advanced melanoma with abnormal genes. The main outcome will be the objective response rate (ORR). This trial is recruiting in California, United States. The details In many cases, melanoma is not diagnosed until an...
Read More
In a nutshell This study evaluated the effectiveness of adding cetuximab (Erbitux) to standard chemotherapy and radiotherapy treatment for advanced non-small cell lung cancer (NSCLC). This study found that adding cetuximab to chemotherapy and radiotherapy resulted in promising outcomes. Some background NSCLC is the...
Read More
In a nutshell This study investigated the benefit of anthracyclines (ATCs) in early breast cancer. They found that this treatment was an effective treatment in patients with early breast cancer. Some background Breast cancer (BC) is one of the most common cancers. Early BC is usually treated with surgery to remove the tumor....
Read More
In a nutshell This phase 1/2 trial is examining the effectiveness of durvalumab (Imfinzi) and monalizumab to treat patients with colorectal cancer or other solid tumors. The main outcomes to be measured are tumor response to the treatment and side effects. The details Cancer is one of the leading causes of death worldwide. Chemotherapy is only of...
Read More
In a nutshell This phase 1/2 trial is examining the effectiveness of durvalumab (Imfinzi) and monalizumab to treat patients with solid tumors, including lung cancer. The main outcomes to be measured are tumor response to the treatment and side effects. The details Cancer is one of the leading causes of death worldwide. Chemotherapy is only of limited...
Read More
In a nutshell This trial is examining the effectiveness of circulating cell-free tumor DNA (cCFTD) as a predictive factor for the treatment of advanced colorectal cancer with regorafenib (Stivarga) or TAS-102. The main outcome to be measured will be to evaluate the ability of early change of cCFTD after the start of the treatment. This trial will be...
Read More
In a nutshell This trial is examining the effectiveness of radiation therapy, in treating patients with high-risk prostate cancer features after radical prostatectomy (surgery to remove the prostate gland). The main outcome to be measured will be freedom from failure. Failure is evidence that the cancer has returned. Patients will be followed up for 5...
Read More
In a nutshell This article reviewed the effectiveness and safety of neratinib (Nerlynx) in patients with human epidermal receptor growth factor 2+ (HER2+) breast cancer. This article concluded that neratinib is effective in treating patients with HER2+ breast cancer, with manageable side effects. Some background Between 15 and 20%...
Read More
In a nutshell This study investigated the effect of X-ray brachytherapy (XRB) in the treatment of patients with rectal cancer who underwent local surgery. Researchers suggested that XRB is associated with improved outcomes and could be used instead of radical surgery. Some background Screening programs increased the number of patients being diagnosed...
Read More
In a nutshell This study evaluated the safety and effectiveness of talimogene laherparepvec (TVEC) therapy for patients with melanoma that cannot be surgically removed (unresectable). The study found that TVEC therapy is an effective treatment for these patients, with minimal side effects. Some background Patients with localized melanoma that is...
Read More
