In a nutshell This study investigated the safety, effectiveness, and side effect profile of chemotherapy given before surgery for the treatment of patients with locally advanced colon cancer (LACC). The data showed that this treatment was safe and effective with manageable side effects for these patients. Some background Colorectal cancer (CRC) is one...
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In a nutshell This study investigated the association between the lowest PSA value after radical prostatectomy (RP; surgery to remove the prostate) and the occurrence of biochemical recurrence (BCR) in patients with localized prostate cancer (PCa). The study found that a higher PSA value after RP and a shorter time to reach this...
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In a nutshell This study investigated the effectiveness of dabrafenib (Tafinlar) plus trametinib (Mekinist) treatment before surgery for patients with unresectable advanced-stage melanoma. The data showed that this treatment was effective before surgery and allowed for the removal of tumors. Some background Melanoma is an aggressive type of skin...
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In a nutshell This study reviewed the role of the addition of radiation therapy (RT) for the treatment of locally advanced rectal cancer (LARC). Researchers suggested that radiation therapy during surgery is associated with a lower recurrence (when cancer comes back) rate. Some background Locally advanced and locally recurrent rectal cancer are...
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In a nutshell This study investigated the effectiveness and outcomes of using prophylactic cranial irradiation (PCI) in patients with non-small cell lung cancer (NSCLC) with a high risk for developing brain metastases (BM). The data showed that PCI significantly decreased the risk of developing BM and increased the overall survival in these...
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In a nutshell This study compared the effectiveness and safety outcomes of radiotherapy (RT) after immediate autologous breast reconstruction (IABR) following breast-conserving surgery (BCS) in patients with breast cancer. The data showed that RT following IABR provided aesthetically satisfactory results with manageable side effects in these...
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In a nutshell This study investigated the outcomes and effectiveness of administering additional (adjuvant) androgen deprivation therapy (A-ADT) for long-term after radiotherapy (RT) in high-risk or very high-risk locally advanced prostate cancer (LAPC). The study found that the addition of A-ADT longer than 1 year after RT showed good treatment outcomes...
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In a nutshell The aim of this study was to evaluate the safety and effectiveness of a cancer vaccine for patients with advanced melanoma. The study found that the vaccine was safe and increased patient survival without worsening of the disease. Some background Treatment for early-stage melanoma includes surgery to remove the tumor. For...
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In a nutshell This study aimed to compare the effectiveness and safety of endocrine therapy (ET) or chemotherapy (CT) before surgery in patients with invasive ductal carcinoma (IDC) of the breast that is hormone receptor (HR) positive (+) and human epidermal growth factor receptor 2 (ERBB2) negative (-). The study concluded CT before...
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In a nutshell The aim of this study was to evaluate different types of therapy after surgery for patients with high-risk melanoma. The study found that add-on targeted therapy or immunotherapy was likely to decrease the risk of disease progression in these patients. Some background Melanoma is a form of skin cancer. Treatment for early-stage...
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In a nutshell This study explored whether trastuzumab (Herceptin) is an efficient drug for the treatment of HER2-positive breast cancer (BC) in patients who have previously received radiotherapy (RT) after breast removal surgery. The authors found that trastuzumab reduced the recurrence of BC and improved survival without cancer coming...
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In a nutshell This study looked at the use of chemotherapy with S-1 (Teysuno) plus cisplatin (Platinol) versus docetaxel (Taxotere) plus cisplatin and radiotherapy (RT) for stage III non-small-cell lung cancer (NSCLC) that cannot be surgically removed. The authors found that S-1 plus cisplatin (SP) should be considered as a treatment...
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