In a nutshell This study examined the use of low-intensity and high-intensity surveillance schedules in the follow-up of breast cancer survivors. Some background The number of women diagnosed with breast cancer rises every year. However, breast cancer treatments have also improved dramatically in recent decades, and mortality rates are...
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In a nutshell This study evaluated which factors can help determine the prognosis of melanoma patients with skin metastases. Some background Melanoma is a type of skin cancer that originates in the pigmented cells of the skin called melanocytes. The 5-year survival rates of patients with melanoma can vary widely, and the prognosis of the disease...
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In a nutshell This study investigated the benefits of chemotherapy to treat inoperable (that cannot be removed through surgery) metastases from colorectal cancer (CRC). Some background When CRC is discovered early, the preferred method of treatment is surgery to remove the cancer along with some surrounding healthy tissue. Chemotherapy is often...
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In a nutshell This study evaluated whether there are specific, high-risk periods a melanoma can return (recur) and spread to distant organs of the body (metastasize). Some background Melanoma is a type of skin cancer that originates in the melanocytes (pigment producing cells of the skin). Often, particularly in the early stages, when the melanoma...
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In a nutshell This study examined whether use of beta-blockers could slow the progression of non small-cell lung cancer. Some background Treatment of non small-cell lung cancer (NSCLC) is often limited due to the rapid progression of the cancer and high recurrence rates. The mechanisms responsible for the rapid spread of NSCLC are unclear, but the...
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In a nutshell This study investigated the relationship between the use of metformin (Glucophage) and prostate cancer mortality. Some background Metformin is a drug commonly used in the management of diabetes. Metformin works by suppressing glucose production in the liver and increasing the body's sensitivity to insulin. Recent studies have...
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In a nutshell This study investigated whether the biology of the cancer called mucinous histology can be used to predict the outcomes of patients with colorectal cancer. The study also evaluated the association between mucinous adenocarcinoma and microsatellite instability. Some background Mucinous histology (MH) is a microscopic observation of...
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In a nutshell This study investigated the long-term safety and efficacy of ipilimumab in patients with advanced melanoma. Some background Patients with advanced melanoma (cancer of the pigmented cells of the skin, called melanocytes, that has invaded beyond the skin or has spread to the lymph nodes or other organs of the body) often benefit from...
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In a nutshell In this study, researchers examined whether levels of a blood marker called microRNA-21 could help predict colorectal cancer (CRC) recurrences. Such information may help select which patients require more intensive follow-up after treatment. Some background MicroRNA consists of small pieces of RNA, a molecule that tells the...
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In a nutshell In this study, researchers examined the safety of surgery for patients with metastatic melanoma who recently received treatment with ipilimumab (Yervoy). Some background Ipilimumab is a drug that uses the patients’ own immune systems to fight cancer cells. It is FDA-approved for the treatment of patients with metastatic...
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In a nutshell This review assessed the effects of neoadjuvant hormonal therapy (NHT) in patients with endocrine-sensitive breast cancer. Some background Endocrine-sensitive breast cancer (also known as hormone receptor-positive breast cancer) refers to breast cancer cells which contain hormone receptors. These receptors (complexes on the...
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In a nutshell This study compared the effectiveness of three adjuvant chemotherapy regimens used in the treatment of node positive breast cancer. Some background Adjuvant chemotherapy refers to chemotherapy given in addition to surgery in an attempt to destroy any remaining cancer cells and to prevent cancer recurrence. Adjuvant chemotherapy is...
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