In a nutshell This study examined the safety and efficiency of OX40 in inducing an immune response against tumors in advanced cancer patients. Some background T cells are a type of white blood cell which can activate or suppress the immune response. Studies have shown that blocking certain receptors on T cells can remove the normal inhibition...
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In a nutshell This clinical trial compared the efficacy and safety of a combined chemotherapy regimen of nab-paclitaxel (Abraxane) plus carboplatin (Paraplatin) versus solvent-based paclitaxel (Taxol) plus carboplatin in patients with advanced non-small-cell lung cancer (NSCLC) basing on the microscopic appearance of the cancer tissue...
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In a nutshell The current study explored the association between sun exposure and melanoma outcome. Some background Physicians normally advise against excessive sun exposure due to the increased risk of skin cancer. However, recent studies have suggested that sun exposure may be associated with lower mortality rates among melanoma patients. The...
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In a nutshell This review evaluated the safety and efficacy of focal salvage ablative therapy for the treatment of patients with prostate cancer recurrence (return of the cancer) after radiation therapy. Some background Radiation therapy (RT) is often used to treat early stage prostate cancer. However, after RT, the cancer may recur, locally...
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In a nutshell This study compared the effect of radiation therapy versus radical prostatectomy (surgical removal of the prostate gland and some healthy tissue around it) on survival rates in patients with prostate cancer (PCa) who had metastasis (cancer spread to distant organs and tissues of the body) after treatment. Some background Radiation...
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In a nutshell This study compared the outcomes of patients treated with laparoscopic and open surgery for low rectal cancer. Some background Keyhole or laparoscopic removal of colorectal cancers is being used more and more frequently. This technique has shown to be beneficial to the patient compared to conventional, open surgery. Laparoscopic...
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In a nutshell This trial investigated the impact of lifestyle changes in diet and exercise on the quality of life (QoL) of advanced prostate cancer (PC) patients. Some background PC can affect patients' QoL as a direct result of the disease itself and as side effects from treatments. Erectile dysfunction (problems obtaining or...
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In a nutshell This present study evaluated the role of menopausal symptoms in the prognosis of breast cancer patients. Some background Menopause is the period in a woman’s life after menstruation stops and the ovaries become inactive, defined as 12 months after a woman's last period. With menopause, the level of female sex hormones such...
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In a nutshell This article reviewed the development and use of biological therapies in the treatment of advanced melanoma, including possible future directions. Some background Targeted molecular therapies and immunotherapies are two commonly used therapeutic approaches for the treatment of advanced melanoma. Targeted molecular therapies...
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In a nutshell This study investigated the cosmetic benefits of intensity modulated radiation therapy (IMRT) compared to standard radiotherapy for the treatment of breast cancer. Some background Radiation therapy is commonly used to treat breast cancer. It is often used following surgery to destroy any remaining cancer cells and prevent recurrence...
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In a nutshell This study examined the effectiveness of routine surveillance imaging in detecting melanoma recurrence and increasing life expectancy. Some background Melanoma survivors are routinely examined for evidence of cancer recurrence since early detection of recurrence significantly improves survival. Although the importance of recurrence...
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In a nutshell This review examined the prognosis of rectal cancer patients exhibiting a partial response to treatment. Some background Treatment of rectal cancer generally includes chemotherapy and/or radiotherapy before surgical removal of the tumor. Response to these treatments is measured by assessing shrinkage of the tumor on a scale referred...
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