In a nutshell The authors aimed to determine the effect of orteronel in patients resistant to hormone treatment. Some background Hormone therapy is commonly used in prostate cancer treatment and involves targeting the male sex hormones active in prostate cancer, such as testosterone. In some cases patients receiving hormone therapy may become...
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In a nutshell The authors aimed to determine whether hormone therapy alone or hormone therapy combined with radiation improved survival in prostate cancer patients. Some background Hormone therapy is a type of prostate cancer treatment that targets the male sex hormones active in prostate cancer, such as testosterone. Radiation therapy...
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In a nutshell The authors aimed to reanalyze data from phase 3 clinical trial of tecemotide in non-small cell lung cancer (NSCLC) patients. Some background NSCLC is the most common type of lung cancer. Standard treatments for inoperable NSCLC (cancer that cannot be removed surgically) are chemotherapy, radiation or a combination of both...
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In a nutshell The objective of this paper was to determine how skin cancer patients with tumor thickness of > 4mm could benefit from a diagnostic procedure known as sentinel lymph node biopsy. Some background Melanoma is a type of cancer that starts in color-producing cells of the skin. It can grow deep into the inner layers of skin...
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In a nutshell This study evaluated the safety and efficacy of adding nimotuzumab (TheraCIM, Theraloc) to radiotherapy plus capecitabine (Xeloda; chemotherapy) for locally advanced rectal cancer. Some background Locally advanced rectal cancer indicates that the tumor has spread to the outer layers of the rectum or has invaded the lymph nodes....
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In a nutshell This study aimed to assess use of dacomitinib in patients with advanced non-small cell lung cancer (NSCLC) who had previously failed to respond to chemotherapy and erlotinib (Tarceva). Some background NSCLC is the most common type of lung cancer. Erlotinib and gefitinib (Iressa) are used to treat NSCLC. They...
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In a nutshell The authors aimed to determine whether specific proteins can predict bone tumors and death in patients with hormone-resistant prostate cancer. Some background In advanced prostate cancer, tumors can spread out from the initial site of cancer to other parts of the body and bones, making treatment difficult. Hormone therapy...
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In a nutshell This paper examined the safety and effectiveness of carboplatin (Paraplatin) and paclitaxel (Taxol) in combination with bevacizumab (Avastin) in triple-negative breast cancer patients. Some background Triple-negative breast cancer describes cancer without the presence of the progesterone receptor, estrogen receptor and human...
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In a nutshell The authors aimed to determine the psychological effect of advanced lung cancer on patients and their family caregivers. Some background Patients with advanced lung cancer experience higher levels of emotional and physical distress compared to patients with other cancers, which can effect their own suffering as well as their...
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In a nutshell The authors aimed to determine the effect of nivolumab in treating malignant skin cancer. Some background Nivolumab (Opdivo) is a man-made immune cell made to attack a specific disease that has been approved for treating malignant skin cancer (cancer that has spread throughout the body). Nivolumab functions by attaching to a...
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In a nutshell This study assessed the safety and efficacy of intensity-modulated radiotherapy plus capecitabine (Xeloda) before rectal surgery. Some background Locally advanced rectal cancer indicates that the cancer has spread beyond the lining of the rectum or has spread to the nearby lymph nodes. Patients with locally advanced rectal cancer are...
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In a nutshell The authors aimed to determine patient and cancer outcome following treatment with pelvic lymph node dissection and robot-assisted prostate surgery. Some background In some prostate cancer patients tumors can spread into the lymph nodes (sites that hold cells used to fight infection). A pelvic lymph node dissection is used to...
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