In a nutshell The authors determined the factors that affected survival in prostate cancer patients with bone tumors when treated with zoledronic acid (Zometa, INN, Reclast). Some background Hormone therapy is commonly used to treat prostate cancer. It involves targeting the male sex hormones active in prostate cancer, such as...
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In a nutshell The authors determined the safety and effectiveness of abiraterone acetate (Zytiga) in patients with metastatic hormone-resistant prostate cancer. Some background Hormone therapy is a common treatment used in prostate cancer. It targets the male sex hormones active in prostate cancer, such as testosterone. Some patients...
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In a nutshell This study looked at the original site of cancer and whether the area it may spread to can be predicted. Some background The location of metastases (where cancer has spread) is an important predictor for survival. It also helps determine the treatment strategy used. If metastases are not detected, it is most often surgery...
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In a nutshell The authors aimed to determine the advantage of neo-adjuvant (treatment given before surgery) therapies in terms of eligibility for certain surgeries. Some background Neo-adjuvant chemotherapy (NAC) is often provided to patients prior to surgery in an attempt to first shrink the tumor. This type of treatment is known to increase the...
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In a nutshell This study looked at the side effects of one chemotherapy regime in colon cancer patients over the age of 70. Some background Surgery is the standard treatment for stage III colon cancer (cancer that has spread beyond the colon to the lymph nodes), while chemotherapy is also effective. A combination of a type of...
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In a nutshell The authors aimed to determine the risks of cancer recurrence (the cancer returns) between the time of hormone or endocrine therapy and the 10 years following. Some background Endocrine therapy is used as treatment against particular cancers that may grow in response to hormones natural to our body. This includes hormone...
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In a nutshell The authors analyzed the effectiveness and safety of retreatment with ipilimumab (Yervoy) in patients with advanced melanoma. Some background The survival rate in advanced melanoma is poor. Ipilimumab, an immunotherapy (treatment that uses the body’s own immune system to fight cancer), is an...
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In a nutshell The authors evaluated a scoring system known as genomic classifier (GC) score that could indicate spread of cancer in prostate canecr patients after surgery and radiation therapy. Some background Prostate surgery and radiation therapy are common treatments in prostate cancer. Prostate surgery involves...
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In a nutshell The authors evaluated the factors that could predict development of brain metastasis in melanoma patients. Some background In advanced melanoma, cancer often spreads to the brain (brain metastasis). The functional changes in the body that accompany the symptoms of brain metastasis are currently unknown. However, if patients are...
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In a nutshell The authors aimed to assess the benefits of prolonged use of hormone therapy to treat breast cancer in women undergoing the menopause transition. Some background Endocrine or hormone therapy is a type of treatment used to fight cancer cells with the presence of hormone receptors (HR+). Hormones natural to our body such as estrogen or...
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In a nutshell The authors determined the effect of cryoablation in locally recurrent (return of cancer to or near the original site) prostate cancer following radiotherapy. Some background Radiotherapy is a common treatment used in prostate cancer. It involves directing a beam of radiation at the tumor site in order to kill cancer...
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In a nutshell The authors aimed to distinguish whether the characteristics of breast cancer could depend on the focality of the tumor. Some background Breast cancer can be characterized as 'unifocal', 'multifocal and 'multicentric'. This refers to the number of areas in which the cancer can be found (focality); unifocal...
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