In a nutshell The authors aimed to determine when radiotherapy should be administered, during chemotherapy-radiotherapy adjuvant treatment in patients with limited small-cell lung cancer (SCLC). They concluded that radiotherapy increases the survival rate if it is administered early during chemotherapy treatment. Some background For SCLC,...
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In a nutshell This study investigated the number of people affected by chemotherapy-induced peripheral neuropathy (CIPN). Risk factors for CIPN, and whether there was an increased risk of falls were also studied. The authors found that most long-term survivors of breast cancer had some CIPN symptoms. Obesity was the main risk factor. Patients...
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In a nutshell This study investigated the effects of CAPOX chemotherapy (oxaliplatin plus capecitabine) or capecitabine (Xeloda) alone on survival of elderly stage 3 colon cancer patients. Researchers suggested that both CAPOX or capecitabine alone were associated with an improved survival. Some background Chemotherapy is the standard...
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In a nutshell This phase 2 trial aims to measure the immune system response to a vaccine to treat melanoma. The main outcome of this trial will be to determine the effectiveness of treatment with vaccine therapy in stage 3 or 4 melanoma patients. The details Immunotherapies stimulate the immune system to fight cancer cells the way it would a virus...
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Hormonal therapy—also known as androgen deprivation therapy—has long been used to treat prostate cancer. But how does it work? And what are the potential side effects? Prostate cancer experts Drs. Jeri Kim and Sumit K. Subudhi, from MD Anderson Cancer Center, explore approved hormonal therapy...
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In a nutshell This trial examined whether the anti-cancer drug axitinib (Inlyta) is safe and effective in combination with chemotherapy for the treatment of advanced squamous non-small-cell lung cancer (NSCLC). The authors conclude that axitinib is safe and has anti-tumor activity. Some background Vascular endothelial...
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In a nutshell This study investigated predictive factors of pelvic lymph node (LN) metastasis (cancer spread to the lymph nodes) and prognostic outcome of having pelvic LN metastasis. Researchers reported that pelvic metastases are associated with worse prognosis and pelvic LN complete removal should be considered in all cases. Some background...
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In a nutshell This study investigated whether complete lymph node removal in patients with positive sentinel lymph node biopsy (SLNB) improved survival. Researchers suggested that complete lymph node removal is not associated with improved survival. Some background SLNB is a procedure used to detect lymph node metastasis (spread of disease) in...
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In a nutshell ?This phase 1/2 trial aims to test the safety and effectiveness of treatment with ipilimumab (Yervoy) in combination with granulocyte macrophage colony stimulating factor (GM-CSF) in patients with stage 3 or 4 melanoma. The main outcome to be measured will be the response of the tumors to treatment. This trial is recruiting in Louisville,...
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In a nutshell This study examined outcomes of different treatment options among older men (aged 70 or older) with high-risk prostate cancer. Authors reported lower disease recurrence rates for prostate surgery compared to radiation and radiation with hormone therapy. Some background Prostate surgery and radiation therapy are both common treatment...
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In a nutshell This study investigated the role of stereotactic body radiotherapy (SBRT) in patients with positive margins (when the cancer is not totally removed) after chemotherapy, radiation therapy and rectal surgery. Researchers suggested that SBRT is an effective and safe treatment option. Some background Chemotherapy and radiation therapy...
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In a nutshell This study investigated the risk of disease recurrence after prostate surgery based on surgical margins. Authors reported an increased risk of disease recurrence among men with close surgical margins. Some background Removal of the prostate gland is a common treatment of localized (confined) prostate cancer. Prostate surgery is...
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