In a nutshell This study evaluated the side effects associated with intensity-modulated radiation therapy (IMRT) for advanced breast cancer. This study found that most side effects were mild and did not lower quality of life for patients. Some background Radiotherapy is often performed in breast cancer patients after surgery. Previous studies have...
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Intensive chemotherapy and breast cancer: is there a benefit to patient survival?
In a nutshell This study investigated chemotherapy regimens in early breast cancer (BC). They found that shortening the duration of treatment improved BC outcomes. Some background Breast cancer (BC) is one of the most common cancers. Standard treatment involves chemotherapy. Standard chemotherapy involves taking a combination of...
Read MoreSearching for patients with early-stage HER2+ breast cancer to trial a new treatment regime
In a nutshell This study will examine how safe and effective the medication atezolizumab (Tecentriq) is in combination with other anti-cancer medicines for treating early stage HER2+ breast cancer. The main outcome that will be measured is how many patients completely respond to treatment, with no trace of the cancer remaining. The details...
Read MoreSearching for patients with non-small cell lung cancer to trial a new anti-cancer drug
In a nutshell This trial is examining a new anti-cancer medication for non-small cell lung cancer called tislelizumab. The main outcome that will be measured is how long it takes for the cancer to start growing again. This study is recruiting across the United States. The details Non-small cell lung cancer (NSCLC) can be...
Read MoreSearching for patients with advanced melanoma to test a new drug combination
In a nutshell This phase 2 trial will investigate the effectiveness of drug combinations including a new drug, spartalizumab (PDR001), in advanced melanoma. The main outcome will be the overall response rate. The details Patients with advanced melanoma have limited treatment options. Surgery may not be a treatment option for many of these...
Read MoreSearching for patients with advanced melanoma to trial a new treatment
In a nutshell This phase 2 trial will investigate the effectiveness of combining relatlimab and nivolumab (Opdivo) to treat melanoma. The main outcomes will be a change in tumor size and response to treatment. This trial is recruiting in Pittsburgh, Pennsylvania, United States. The details Melanoma is a type of skin...
Read MoreSearching for patients with advanced melanoma to trial a new anti-cancer vaccine
In a nutshell This trial aims to find out if a new vaccine called NEO-PV-01 is safe to use in the treatment of advanced melanoma in combination with ipilimumab (Yervoy) or APX005M and with nivolumab (Opdivo). The main outcomes that will be measured will be side effects and response to treatment. The study is being conducted in the United...
Read MoreSurvival in patients with melanoma treated with pembrolizumab
In a nutshell This study wanted to find out what the survival rates are of patients with melanoma treated with pembrolizumab (Keytruda). The study found that after 5 years, there was a good response to treatment overall. Some background Pembrolizumab is a new cancer treatment. It treats many different types of cancer. It works by using the immune...
Read MoreSearching for patients with advanced breast cancer to trial a new medication
In a nutshell This trial is aiming to determine how effective a new medication called elacestrant is for treating advanced breast cancer. The main outcome that will be measured is how long the patients go without the disease progressing. This study is being conducted in Illinois, United States. The details Some breast cancers grow in response to the...
Read MoreIntraoperative electron radiotherapy in treating breast cancer
In a nutshell This study wanted to find out what benefits there were to doing electron radiation therapy during surgery alongside normal radiation therapy for women with breast cancer. The study found that ten years after surgery, almost all the patients who had electron radiotherapy during surgery had no reoccurrence of breast cancer. Some...
Read MoreTreating non-small cell lung cancers that have spread.
In a nutshell This paper is about how to diagnose, treat, and follow up on non-small cell lung cancer cases that have spread through the body. The paper overall noted that non-small cell lung cancer which has spread is often very aggressive and hard to treat, and that methods of treatment are still being developed. Some background Non-small...
Read MoreThe effect of FDG-PET imaging on patients with melanoma treated with immunotherapy.
In a nutshell The study looked at the use of FDG-PET imaging to assess long-term outcomes of treatment in patients with melanoma. Researchers found that FDG-PET imaging may be useful in predicting long-term outcomes of treatment in these patients. Some background Treatment for melanoma has vastly improved in recent years. Immunotherapies have improved...
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