In a nutshell This study wanted to find out which was the better treatment for advanced melanoma that has been surgically treated, ipilimumab (Yervoy) or high dose interferon alfa (HDI). The study found that low dose ipilimumab resulted in better overall survival than HDI and high dose ipilimumab, but all of the treatments had...
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Are abdominal infections a prognostic factor for recurrence after colorectal cancer surgery?
In a nutshell This study investigated whether tummy infections (TIs) after surgery are associated with colorectal cancer outcomes. Researchers suggested that TIs might be associated with a shorter time until recurrence. Some background Colorectal cancer is a common cancer in the US affecting more than 145,000 people every year. Surgery is...
Read MoreEvaluating outcomes of immunotherapy for melanoma before and after surgery
In a nutshell This study wanted to find out what the best order is for treating melanoma with immunotherapy medications and surgery. The study found that immunotherapy before surgery resulted in better survival outcomes for these patients. Some background Treatments for melanoma have changed in the last few years. A newer treatment is...
Read MoreEvaluating osimertinib on the outcomes of patients with untreated non-small cell lung cancer
In a nutshell This study examined the safety and effectiveness of osimertinib (Tagrisso) compared to other targeted therapies for advanced non-small cell lung cancer (NSCLC). The authors concluded that osimertinib improved patient survival. Some background NSCLC accounts for the majority of lung cancers. Some...
Read MoreDurvalumab after chemoradiotherapy for non-small cell lung cancer: analysis from the patients’ perspective
In a nutshell This study evaluated the patient-reported outcomes after treatment with durvalumab (Imfinzi) for stage III non-small-cell lung cancer (NSCLC) that cannot be surgically removed. This study concluded that durvalumab did not affect the quality of life of these patients. Some background NSCLC is the most common form of lung cancer...
Read MoreComplete mesocolic excision reduces the risk of recurrence in patients with colon cancer
In a nutshell This study investigated the effects of complete mesocolic excision (CME) in patients with right-side colon cancer. Researchers suggested that CME reduces the risk of recurrences (when cancer comes back) in these patients. Some background Colorectal cancer is one of the most common cancers worldwide. The standard treatment is surgery and...
Read MoreRadiation therapy after surgery improves survival of patients with advanced colon cancer
In a nutshell This study investigated the effectiveness of radiation therapy (RT) after surgery in patients with T4 (cancer that has grown outside of the colon outer layer and invades the surrounding tissues) colon cancer. Researchers suggested that RT improved overall survival in these patients. Some background Colorectal cancer is the third...
Read MoreEvaluating the outcomes of patients with advanced melanoma with different treatments
In a nutshell This study wanted to find out how well patients with advanced melanoma treated with certain medications survived outside of clinical trials. The study found that patients treated with nivolumab (Opdivo) and ipilimumab (Yervoy) or patients treated with anti-PD1 antibodies had longer survival compared to those treated with BRAF/MEK...
Read MoreChemotherapy improves survival of patients with mucinous colorectal adenocarcinoma
In a nutshell This study investigated the effect of chemotherapy on the survival of patients with stage 2 and 3 mucinous colorectal cancer (mucCRC). Researchers suggested that chemotherapy improved the survival of these patients. Some background Colorectal cancer is the third most common cancer in the US in 2019. Up to 20% of colon cancer is mucCRC....
Read MoreReview of treatment options for patients with advanced melanoma
In a nutshell This article reviewed treatment options for patients with advanced melanoma. Some background Treatment for melanoma depends on several factors, including the disease stage. Advanced melanoma is diagnosed when cancer can be detected outside of the original tumor. This makes treatment difficult. Currently, there...
Read MoreLooking for patients with advanced triple negative breast cancer to test an experimental drug with three functions
In a nutshell This trial is examining the safety and effectiveness of experimental drug mRNA-2752 in patients with advanced triple-negative breast cancer. The main outcome of the trial will be the number of side effects experienced by patients and response to treatment. This trial is recruiting in the United States and Israel. The details...
Read MoreLooking for postmenopausal women with advanced breast cancer to try a hormonal therapy
In a nutshell This study is looking for postmenopausal patients with advanced breast cancer with an ESR1 mutation to compare lasofoxifene (Fablyn) to fulvestrant (Faslodex). The main outcome measured in this trial will be the patient’s survival without tumor growth or spread. This trial is recruiting in multiple locations in the United...
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