In a nutshell This study wanted to see how well two medications worked in treating advanced triple negative breast cancer, atezolizumab (Tecentriq) and nab-paclitaxcel (Abraxane). The study found that using these two medications together improved survival in these patients. Some background Triple-negative breast cancer (TNBC) is breast cancer...
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Metronomic chemotherapy for HR+ advanced breast cancer
In a nutshell This study wanted to see how well using metronomic chemotherapy with capecitabine (Xeloda) combined with aromatase inhibitors works for patients with hormone receptor positive advanced breast cancer. The study found that this treatment works well and is safe, and therefore should be considered as a potential treatment option. Some...
Read MoreTreatment for advanced melanoma with abnormal genes
In a nutshell This study wanted to find out which treatment for melanoma cancer worked better, encorafenib (Braftovi) + binimetinib (Mektovi), encorafenib alone, or vemurafenib (Zelboraf) alone. The study found that encorafenib + binimetinib worked well and was safe, compared to vemurafenib and encorafenib. Some background In about 50% of patients...
Read MorePalbociclib and Fulvestrant in Advanced Breast Cancer.
In a nutshell This study investigated the overall survival rates of people with breast cancer who were treated with either palbociclib (Ibrance) plus fulvestrant (Faslodex), or just fulvestrant. The study found that the patients who received both palbociclib and fulvestrant had a longer overall survival compared to the group who only received...
Read MoreLaparoscopic surgery is associated with improved quality of life in patients with colon cancer
In a nutshell This study compared open surgery to laparoscopic surgery (LS; a tube with a camera is inserted through a small cut to remove the tumor) in terms of quality of life in patients with colon cancer. Researchers suggested that patients treated with LS had an improved quality of life after surgery. Some background Colon cancer is...
Read MoreTVEC as a treatment for advanced melanoma
In a nutshell This study analysed a treatment for late-stage melanoma called talimogene laherparepvec (TVEC). It found that treating late-stage melanoma with TVEC was effective, and had only minor side effects. Some background Talimogene laherparepvec (TVEC) (Imlygic) is a treatment used for late-stage melanoma which is unable to be operated on. TVEC...
Read More10 years of treatment vs 5 years of treatment with hormone therapy in patients with early stage breast cancer.
In a nutshell This study wanted to find out if continuing hormone therapy for 10 years was more effective than doing it for 5 years in patients with early stage breast cancer. The study found that the patients who continued treatment for 10 years survived for longer without the disease coming back compared to those who were only treated for 5...
Read MoreThe effect of FDG-PET imaging on patients with melanoma treated with immunotherapy.
In a nutshell The study looked at the use of FDG-PET imaging to assess long-term outcomes of treatment in patients with melanoma. Researchers found that FDG-PET imaging may be useful in predicting long-term outcomes of treatment in these patients. Some background Treatment for melanoma has vastly improved in recent years. Immunotherapies have improved...
Read MoreChemotherapy before surgery in the treatment of high risk rectal cancer
In a nutshell This study investigated the outcomes of chemotherapy before surgery in patients with high-risk rectal cancer. Researchers suggested that chemotherapy improves tumor shrinkage before rectal surgery. Some background The standard treatment for patients with rectal cancer is surgery. High-risk patients may benefit from short-course...
Read MoremFOLFOX6 and XELOX have similar side effect rates stage 3 colon cancer
In a nutshell This study investigated the safety of the chemotherapies mFOLFOX6 and XELOX in Japanese colon cancer patients. Researchers suggested that the safety of both treatments is acceptable. Some background FOLFOX chemotherapy is the standard treatment for stage 3 colon cancer patients who underwent surgery. mFOLFOX6 combines leucovorin,...
Read MoreDoes Sentinel lymph node status have any impact on survival from melanoma?
In a nutshell This study investigated if sentinel lymph node (SLN) status was linked to Breslow thickness in understanding the prognosis of melanoma (a type of skin cancer). The study concluded that SLN status was not linked to Breslow thickness (BT) for melanoma prognosis. Some background Sentinel lymph nodes...
Read MorePembrolizumab improves stage 3 melanoma outcomes
In a nutshell This study investigated the effectiveness of pembrolizumab (Keytruda) in the treatment of patients with stage 3 melanoma who underwent surgery. Researchers suggested that this drug is associated with longer recurrence-free survival with no new side effects. Some background The use of PD-1 antibodies, such as pembrolizumab, in patients...
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