In a nutshell This study created a computer simulation of prostate cancer that calculates the risk of overtreatment in older men. Authors concluded that individual characteristics such as age, number of medical conditions, and cancer stage at diagnosis affect the probability of overtreatment and the potential benefit of active treatment. Some...
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In a nutshell This study examined predictors of mortality risk in older prostate cancer patients treated with surgery. Authors reported that blood vessel disorders, severity of a whole-body disease, smoking status, and education level were significant predictors of mortality in older men treated with surgery. Some background Radical treatment...
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In a nutshell This study examined evidence for the role of prostate surgery in treating high-risk prostate cancer. Authors concluded that surgery is an effective primary treatment option for men with high-risk disease. Some background Localized prostate cancer is cancer that is confined to the prostate gland. Men with high-risk localized prostate...
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In a nutshell This study examined the benefit of biopsies guided by multiple imaging techniques (scans that provide images of the interior of the body) in men managed with active surveillance. Researchers reported improved detection rates of disease progression when biopsies were guided by multiple imaging techniques. Some background Many men with...
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In a nutshell This study investigated the outcomes of lower third rectal cancer patients treated with chemotherapy and radiation therapy (CRT). Researchers suggested that CRT could be beneficial for lower rectal cancer patients. Some background The most adequate treatment for lower rectal cancer is still a challenge. Prior studies suggested...
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In a nutshell This study investigated proteins (blood factors) in patients with early-stage melanoma that identify those at a high risk of experiencing metastasis (cancer spread) after surgery. Researchers suggested that tumor stage and proteins such as vitronectin (VN) and dermcidin (DCD) levels were associated with the metastatic progression of...
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In a nutshell This review examined findings on lifestyle interventions for men with prostate cancer managed with active surveillance. The authors reported preliminary evidence on the benefits of physical exercise for men undergoing active surveillance. Some background Due to advances in the early detection of prostate cancer, many prostate tumors...
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In a nutshell This study examined the risk of recurrence following early-stage non-small cell lung cancer (NSCLC) treated with surgery. The authors showed that the risk of relapse after surgery changes in a predictable way over time, where the first two years after surgery has the highest risk of relapse. They noted that the risk then declines but...
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In a nutshell This study investigated the effectiveness of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients with early stage peritoneal metastasis (PM; when the cancer spreads to the abdominal lining). Researchers suggested that HIPEC may benefit these patients. Some background The peritoneal region is the second...
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In a nutshell The authors aimed to determine the risks of unfavorable disease and predictors of adverse outcomes in men with Gleason score 3 + 4 prostate cancer and how this would affect active surveillance. The authors concluded that active surveillance is a potential treatment option in men with Gleason score 3+4, low PSA scores and low-stage...
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In a nutshell The authors aimed to determine when radiotherapy should be administered, during chemotherapy-radiotherapy adjuvant treatment in patients with limited small-cell lung cancer (SCLC). They concluded that radiotherapy increases the survival rate if it is administered early during chemotherapy treatment. Some background For SCLC,...
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In a nutshell This study investigated the number of people affected by chemotherapy-induced peripheral neuropathy (CIPN). Risk factors for CIPN, and whether there was an increased risk of falls were also studied. The authors found that most long-term survivors of breast cancer had some CIPN symptoms. Obesity was the main risk factor. Patients...
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