In a nutshell This trial compared standard chemotherapy regimens and Capecitabine (Xeloda) in women over 65 years old. The main outcome was that standard chemotherapy worked better in this age group. Some background Capecitabine is generally used in breast cancer resistant to other chemotherapy. It is also the first approved treatment that can be...
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In a nutshell The present study evaluated whether the presence of cancer cells in the blood stream predicts a worse prognosis in women with operable breast cancer. The main finding was that progression-free survival (time before cancer progression) and overall survival were lower if circulating cancer cells were detected in the blood. Some background...
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In a nutshell This study evaluated whether focal Ultrasound-based therapy of individual cancer lesions can minimize the side effects associated with radical therapy that involves the whole prostate gland. Main findings: Focused therapy directed into cancer tissues significantly reduces genitourinary side effects like urine-leakage and impotence. Some...
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In a nutshell This study compared intermittent versus continuous androgen deprivation therapy (ADT) for localized (confined) prostate cancer due to prostate-specific antigen (PSA) elevation after radiotherapy. Main findings: Intermittent ADT was not inferior compared to continuous therapy with respect to survival. However, some quality of life...
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In a nutshell The present study evaluated a new biomarker that could be used to predict recurrence of prostate cancer after surgical removal of the prostate gland (prostatectomy). Three proteins called Sp1/Sp3/FLIP, combined with the Gleason score were found highly prognostic in the prediction of recurrence, and can therefore help guiding the initial...
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In a nutshell The present study compares two surgical techniques for the treatment of colon cancer: Open Colectomy (OC) and Laparoscopic Assisted Colectomy (LAC). They found that LAC may be preferred to OC for removal of colon cancer. Some background The first treatment of choice for colon cancer which is localized to the colonic...
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Colorectal cancer is the uncontrolled growth of cells in the rectum, colon (the large intestine) and it can also affect the appendix. It affects both men and women. Patients who are diagnosed with stage 1 and 2 colorectal cancer (cancers affecting the lining of the intestines – stage 1, and the muscle wall – stage 2) are generally only...
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This paper reviews chemotherapy options for triple-negative breast cancers. Breast cancer cells express 3 main receptors that can be targeted with therapy: Estrogen receptors (ER), Progesterone receptors (PR) and HER2. Triple-negative breast cancers (TNBCs) do not express these 3 receptors and make up approximately 15% of breast cancers. Such tumors do...
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