In a nutshell This phase 3 clinical trial assessed the efficacy and safety of radium-223 dichloride or radium-223 (Xofigo) in patients with prostate cancer that has spread to the bone. Some background Testosterone, the main male sex hormone, promotes the growth of prostate cancer. A treatment option for prostate cancer patients is castration...
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In a nutshell In the past several years, the treatment of prostate cancer has made significant progress. In this study, researchers reviewed recent studies evaluating treatments for patients with prostate cancer. Some background Prostate cancer progression is usually measured by blood levels of a protein called prostate-specific antigen (PSA) in a...
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In a nutshell This study used a simulation model to review the benefits and harms of either treating, or simply observing, patients diagnosed with prostate cancer by prostate specific antigen screening. Some background Prostate specific antigen (PSA) is a molecule produced by cells of the prostate gland, and is normally present at very low levels...
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In a nutshell This study looked at men with prostate cancer undergoing active surveillance, and tried to show which characteristics were related with an increased risk of cancer progression. Some background Prostate cancer is the uncontrolled growth and division of prostate cells. This growth can be slow and sometimes harmless, so in the...
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In a nutshell The present study evaluated the effect of Abiraterone acetate (AbAc) on survival and disease progression, when given to patients with metastatic prostate cancer (mPC) that is resistant to hormone therapy (castration-resistant). Some background Prostate cancer (PCa) growth is fueled by male hormones like...
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In a nutshell This article reports the results of recent studies involving the drug Docetaxel (Taxotere). The drug did not improve overall survival when added to androgen-deprivation therapy. Smaller doses given in shorter treatment cycles were found to be easier to tolerate and more effective. Some background Prostate cancer grows in...
Read MoreDue to the increase in life expectancy, there exists an increasing number of patients with prostate cancer (PCA) in many populations. However, there is no consensus on screening and treatment of PCA in the medical fraternity. This paper investigated the oncological outcomes of radical prostatectomy (RP) in older men (> 70) compared to RP outcomes in...
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The aim of this article was to describe some of the most interesting developments concerning new therapies for advanced prostate cancer. During the last years new experimental therapeutic agents for the treatment of advanced prostate cancer have been developed. These are based on the recent discoveries on prostate cell function, resistance to...
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In a nutshell This clinical trial evaluated the survival benefits of a drug named Enzalutamide (Xtandi) for patients with non-responsive (refractory) advanced prostate cancer previously treated with chemotherapy. Main findings: Enzalutamide prolonged survival by approximately 5 months and reduced the risk of death by 37%. Some background The...
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In a nutshell The present study assessed the efficiency of a drug named Denosumab in delaying the spread of prostate cancer to the bone in men with resistant prostate cancer (not responding to hormone therapy and surgery). The results show that the drug tested delayed bone involvement by few months. Some background Bone metastases are...
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Regretfully, metastatic forms of prostate cancer (spread to distant sites via the blood system) treated with chemotherapy often acquire resistance to the drug, partially due to the repetitive nature of treatment. Resistance leads to tumor progression and treatment failure. This scientific article proposes a novel therapeutic target named WNT16B that...
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In a nutshell This study evaluated whether focal Ultrasound-based therapy of individual cancer lesions can minimize the side effects associated with radical therapy that involves the whole prostate gland. Main findings: Focused therapy directed into cancer tissues significantly reduces genitourinary side effects like urine-leakage and impotence. Some...
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