In a nutshell This study examined the role of active surveillance in the management of intermediate-risk prostate cancer. Researchers concluded that active surveillance is a safe management method for selected patients with favorable intermediate-risk disease. Men with more aggressive cancer cells may benefit from active treatment early on. Some...
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In a nutshell This study examined the benefit of biopsies guided by multiple imaging techniques (scans that provide images of the interior of the body) in men managed with active surveillance. Researchers reported improved detection rates of disease progression when biopsies were guided by multiple imaging techniques. Some background Many men with...
Read MoreIn a nutshell This trial aims to examine stereotactic radiosurgery guided by an imaging technique in treating low- to intermediate-risk prostate cancer. The main outcome to be investigated is treatment-related side effects and treatment response. The trial is recruiting in Ohio (USA). The details Stereotactic radiosurgery (SRS) uses a specially...
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In a nutshell The authors aimed to determine the risks of unfavorable disease and predictors of adverse outcomes in men with Gleason score 3 + 4 prostate cancer and how this would affect active surveillance. The authors concluded that active surveillance is a potential treatment option in men with Gleason score 3+4, low PSA scores and low-stage...
Read MoreIn a nutshell This study compared prostate surgery and radiation therapy in treating high-risk prostate cancer. Authors reported similar survival benefits with both treatments. However, high doses of total radiation combined with hormone therapy was associated with the lowest risk of disease progression. Some background Prostate surgery and...
Read MoreIn a nutshell This study examined the effect of combined radiation and hormone therapy on long-term fatigue. Researchers reported severe fatigue during and up to 4 years after treatment. Men with increased cancer markers and symptoms were more likely to report higher fatigue levels. Some background Radiation therapy and hormone therapy are often...
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In a nutshell This study examined the evidence for combining androgen deprivation therapy (ADT) with radiation therapy for the treatment of high-risk localized prostate cancer. Authors concluded that the combined therapy approach was associated with a survival advantage for intermediate- and high-risk patients. Some background ADT is a type...
Read MoreIn a nutshell This phase 3 trial aims to evaluate the benefit of a diet and exercise program in overweight men with low-risk prostate cancer. The main outcome to be investigated is a change in blood sugar metabolism in prostate cancer cells. The trial is recruiting in Seattle (Washington), USA. The details Low-risk prostate cancer is often managed...
Read MoreIn a nutshell This phase III trial aims to evaluate if metformin (Glucophage) can delay the time to progression in men with low-risk prostate cancer. The main outcome to be investigated is disease progression based on the need for treatment or biopsy results. The trial is recruiting in several locations in Canada. The details Metformin is a drug...
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In a nutshell This study examined abiraterone acetate (Zytiga) as a treatment option for older men with metastatic castration-resistant prostate cancer. Researchers concluded that abiraterone acetate improves overall survival in younger as well as older men with metastatic castration resistant prostate cancer. Some background...
Read MoreIn a nutshell This study examined the effectiveness of multiparametric magnetic resonance imaging (mpMRI) in predicting cancer progression during active surveillance. Researchers concluded that mpMRI adds value to biopsy results in identifying the risk of cancer progressing. Some background Active surveillance is common in low-risk...
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In a nutshell The authors determined the association between perineural invasion (cancer on the nerves inside the prostate) and disease progression in men with prostate cancer on active surveillance (watchful waiting). Some background Active surveillance is common in early stage (stage I or II) prostate cancer. It involves actively...
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