In a nutshell This phase 2 trial will investigate the safety and effectiveness of nivolumab (Opdivo) in recurrent prostate cancer (PC). The main outcome will be disease control. This trial is recruiting at two locations in Boston, MA, US. The details Prostate cancer (PC) is a highly treatable cancer in men. Patients are usually...
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In a nutshell This trial is examining the effectiveness of radiation therapy, in treating patients with high-risk prostate cancer features after radical prostatectomy (surgery to remove the prostate gland). The main outcome to be measured will be freedom from failure. Failure is evidence that the cancer has returned. Patients will be followed up for 5...
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This study compared the outcome of low-dose rate brachytherapy (LDR-BT) and image-guided intensity-modulated radiotherapy (IG-IMRT) for different severities of localized prostate cancer. Five year survival rates will almost the same across both treatments. Five year biochemical failure free survival rates were higher for patients treated with LDR-BT...
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In a nutshell This study aimed to determine which patients benefited most from abiraterone acetate (Zytiga) and prednisone (Deltasone). This study found that overall survival was increased for all patient groups that received this combination. Some background A main treatment option for prostate cancer is androgen deprivation...
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In a nutshell The aim of this trial was to determine the difference in quality of life on urination when treated with low dose rate (LDR) and high dose rate (HDR) brachytherapy. This study is being conducted in Kelowna, British Columbia, Canada. The details Brachytherapy is a form of radiation therapy that places radioactive material either within...
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In a nutshell The authors aimed to determine the influence of biopsy timing on prostate cancer reclassification during active surveillance. The authors concluded that the timing of the first biopsy was not related to an increased risk of cancer reclassification, but prostate specific antigen (PSA) and body mass index (BMI – measured based...
Read MoreIn a nutshell The authors aimed to determine how anxiety and uncertainty affects men with prostate cancer who are undergoing active surveillance. The authors concluded that uncertainty and urinary complications promote anxiety in men on active surveillance for prostate cancer. They also recommend patient education and management of urinary...
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In a nutshell The aim of this study was to see if ultrasounds could be used as a tool to monitor low-risk prostate cancer patients in active surveillance. It was concluded that ultrasounds can be used to monitor changes in prostate cancer, and could extend the time between biopsies. Some background Low-risk prostate cancer is cancer that has not...
Read MoreIn a nutshell This study compared external beam radiation therapy (EBRT) and hypofractioned EBRT (H-EBRT) for low-risk localized prostate cancer. Researchers reported no differences in disease progression or survival. However, an increase in side effects was observed with H-EBRT. Some background Radiation therapy is a common treatment for...
Read MoreIn a nutshell This review examined recent findings and recommendations for the management of low-risk localized prostate cancer. Authors concluded that watchful waiting and active surveillance are suitable options for most men with low-risk prostate cancer. Some background Due to advances in the early detection of prostate cancer, many prostate...
Read MoreIn a nutshell This phase 1/2 trial aims to evaluate the effectiveness of a short course of very focused radiation therapy in the treatment of early stage prostate cancer. The main outcome to be investigated is side effects and treatment response. The trial is recruiting in San Diego, California (USA). The details External beam radiation therapy...
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In a nutshell This study examined the relationship between comorbidities (other medical conditions) and cancer progression during active surveillance. Researchers reported that progression is more likely among men with 2 or more comorbidities. Some background Active surveillance of prostate cancer refers to actively monitoring tumor growth...
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