In a nutshell This trial is looking at blocking androgens (male sex hormones) with different medications in men with raised PSA (a blood marker of prostate cancer) levels after prostate surgery. The main outcome to be measured will be the length of time the patients survive without the cancer progressing. This study is being conducted in the United...
Read MoreCurrent Gleason score-7 Posts on Medivizor
Long term results discussing radiotherapy and hormone therapy treatments for patients with prostate cancer
In a nutshell This study aimed to evaluate whole pelvic radiotherapy (WPRT) compared to prostate only radiotherapy (PORT) with hormonal therapy (HT) before or after radiation for patients with intermediate- or high-risk prostate cancer. This study found that HT before radiotherapy and WPRT had superior long-term survival without cancer growing or...
Read MorePartial gland ablation versus prostate surgery in men with low- or intermediate-risk prostate cancer
In a nutshell The authors aimed to determine patient outcomes following partial gland ablation compared to robot-assisted radical prostate surgery in men with low- and intermediate- risk prostate cancer. The authors concluded that men with cancer confined to the prostate benefited from partial gland ablation, as it was more successful with fewer side...
Read MoreTreatments available for advanced, hormone-resistant prostate cancer
In a nutshell The authors aimed to determine guidelines for the treatment of relapsing, metastatic, and hormone-resistant prostate cancer. Some background Metastatic prostate cancer (advanced cancer) is cancer that has spread outside of the prostate to other organs of the body, despite treatment. Hormone therapy is the standard...
Read MoreCan ultrasounds be useful during active surveillance for prostate cancer?
In a nutshell The aim of this study was to see if ultrasounds could be used as a tool to monitor low-risk prostate cancer patients in active surveillance. It was concluded that ultrasounds can be used to monitor changes in prostate cancer, and could extend the time between biopsies. Some background Low-risk prostate cancer is cancer that has not...
Read MoreThe role of active surveillance for men with intermediate-risk prostate cancer
In a nutshell This study examined the role of active surveillance in the management of intermediate-risk prostate cancer. Researchers concluded that active surveillance is a safe management method for selected patients with favorable intermediate-risk disease. Men with more aggressive cancer cells may benefit from active treatment early on. Some...
Read MoreHormone therapy during or after radiation therapy increases the risk of cardiovascular events
In a nutshell This study examined the effect of androgen deprivation therapy (ADT) on the risk of cardiovascular events (such as stroke or heart attack) in men treated with radiation therapy. Researchers concluded that ADT use during or after radiation therapy increases the risk of cardiovascular events. Some background Radiation therapy is a...
Read MoreRisk factors, unfavorable disease and the implications for active surveillance in early-stage prostate cancer
In a nutshell The authors aimed to determine the risks of unfavorable disease and predictors of adverse outcomes in men with Gleason score 3 + 4 prostate cancer and how this would affect active surveillance. The authors concluded that active surveillance is a potential treatment option in men with Gleason score 3+4, low PSA scores and low-stage...
Read MoreExamining the rate of disease upgrading during active surveillance
In a nutshell This study analyzed the rates of disease upgrading after biopsy (tissue sample) tests in men with low-risk prostate cancer. Researchers concluded that men with low-risk prostate cancer have a very low risk of being upgraded during active surveillance. Some background Most men diagnosed with prostate cancer are categorized as low...
Read MoreExamining high-intensity focused ultrasound for unilateral prostate cancer
In a nutshell This study examined the effectiveness of high-intensity focused ultrasound (HIFU) in treating unilateral prostate cancer (only affecting one side). Authors reported good cancer control and a low rate of side effects. Some background Advances in cancer screening methods have led to earlier diagnoses of prostate cancer. Most are...
Read MoreExamining the benefits of combining hormone therapy and radiation therapy
In a nutshell This study examined the evidence for combining androgen deprivation therapy (ADT) with radiation therapy for the treatment of high-risk localized prostate cancer. Authors concluded that the combined therapy approach was associated with a survival advantage for intermediate- and high-risk patients. Some background ADT is a type...
Read MoreManagement of high-risk prostate cancer – a summary of findings
In a nutshell This review evaluated recent evidence on the management of high-risk prostate cancer. Primary treatment options for high-risk prostate cancer were generally associated with good effectiveness, but authors advised that risk assessment is in need of refinement and standardization. Some background About 15% of men with prostate cancer...
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