In a nutshell The study evaluated real-life benefits of autologous hematopoietic stem cell transplantation (ASCT) after immune checkpoint inhibitor (CPi) therapy in patients with relapsed/refractory (r/r) Hodgkin lymphoma (HL). The authors found that ASCT can be an effective option after CPi therapy in such patients. Some background Some patients...
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Seeking patients with relapsed follicular lymphoma for dosing study of idelalisib
In a nutshell This study will evaluate the best dose of idelalisib (Zydelig) for patients with relapsed follicular lymphoma (FL). The primary outcomes are overall response and side effects. The details FL is a slow-growing cancer of B-cells, a type of white blood cell. Idelalisib is a medication that inhibits certain proteins involved in...
Read MoreEvaluating haploidentical stem cell transplantation for advanced lymphoma
In a nutshell This study looked at the effect of a gentler stem cell transplant (SCT) from a partially matched donor for patients with advanced lymphoma. It found that haploidentical SCT is an effective treatment option for these patients. Some background Lymphomas are a group of cancers of white blood cells within the lymph nodes. Common types...
Read MoreEvaluating haploidentical stem cell transplantation for advanced lymphoma
In a nutshell This study looked at the effect of a gentler stem cell transplant (SCT) from a partially matched donor for patients with advanced lymphoma. It found that haploidentical SCT is an effective treatment option for these patients. Some background Lymphomas are a group of cancers of white blood cells within the lymph nodes. Common types...
Read MoreEvaluating low-dose pembrolizumab and nivolumab for relapsed or refractory classical Hodgkin lymphoma.
In a nutshell This trial was carried out to examine the effectiveness and safety profile of pembrolizumab (Keytruda) and nivolumab (Opdivo) for the treatment of classical Hodgkin lymphoma (cHL) that has relapsed and is refractory (resistant to drug treatment). The authors found that...
Read MoreOutcomes of lisocabtagene maraleucel in patients with relapsed or refractory large B-cell lymphomas
In a nutshell The study evaluated the effectiveness and safety of lisocabtagene maraleucel (Liso-cel) in treating patients with relapsed or refractory (r/r) large B-cell lymphomas (LBCL). The authors found that liso-cel achieved fast and lasting remission with fewer toxicities in such patients. Some background Patients with r/r-LBCL experience...
Read MoreThe effects of a second autologous stem cell transplantation in patients with relapsed/refractory Hodgkin lymphoma after a first transplant
In a nutshell The study evaluated the outcomes of second autologous stem cell transplantation (ASCT2) in patients with relapsed/refractory Hodgkin lymphoma (r/r-HL) after a first transplantation (ASCT1). The main finding was that ASCT2 was safe and relatively effective in such patients. Some background ASCT replaces cancerous bone marrow with healthy...
Read MoreCan immunotherapy increase the effectiveness of following treatments for patients with relapsed or unresponsive non-Hodgkin lymphoma?
In a nutshell This study examined if pre-treatment with immunotherapy could improve the effectiveness of following treatment for patients with hard-to-treat non-Hodgkin lymphoma (NHL). The results indicated that immunotherapies increased the effectiveness of other treatments such as chemotherapy for some patients. Some background While...
Read MoreZanubrutinib treatment for relapsed or unresponsive small lymphocytic lymphoma
In a nutshell This study aimed to investigate the safety and effectiveness of zanubrutinib in patients with relapsed/unresponsive chronic lymphocytic leukemia and small lymphocytic lymphoma. This study concluded that zanubrutinib was well tolerated and with promising effectiveness in these patients. Some background Bruton tyrosine...
Read MoreHow safe and effective is targeted therapy abemaciclib for patients with relapsed or refractory mantle cell lymphoma?
In a nutshell This study examined the safety and effectiveness of targeted therapy abemaciclib (Verzenio) for patients with relapsed or refractory mantle cell lymphoma (MCL). The results showed that abemaciclib had promising effectiveness and was relatively safe in these patients. Some background MCL is an aggressive type of lymphoma. During...
Read MoreEvaluating brentuximab vedotin plus bendamustine for patients with hard-to-treat classical Hodgkin lymphoma
In a nutshell This study evaluated the effectiveness of brentuximab vedotin (Adcetris) plus bendamustine (Treanda) for patients with hard to treat classical Hodgkin lymphoma (cHL). This study found that this regimen is an effective salvage therapy for these patients. Some background Standard first-line chemotherapy is highly effective in treating...
Read MoreEvaluating BEB chemotherapy for patients with non-Hodgkin’s lymphoma
In a nutshell This study evaluated the safety and effectiveness of BEB (busulfan, etoposide, bendamustine) chemotherapy for patients with non-Hodgkin’s lymphoma (NHL). This study found that BEB chemotherapy was effective and well-tolerated in these patients. Some background Autologous stem cell transplantation (ASCT) is a standard...
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