In a nutshell This phase 3 trial will investigate the effectiveness of 2 experimental drugs, DS-8201a vs T-DM1, for the treatment of breast cancer (BC). The main outcome will be survival without cancer worsening. The details Breast cancer (BC) is a common and treatable form of cancer. Cancers, including BC, can be categorized depending on certain...
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Searching for patients with breast cancer to test a new treatment
In a nutshell This phase 3 trial will investigate the effectiveness of a new drug, DS-8201a, in the treatment of unresectable/metastatic breast cancer (UMBC). The main outcome will be survival without cancer worsening. The details Breast cancer (BC) originates from tissue in the breast. BC is treated with surgery to remove the cancer or...
Read MoreSearching for patients with small-cell lung cancer or neuroendocrine tumors to trial a new treatment regime
In a nutshell This trial aims to find out how well nivolumab (Opdivo) and temozolomide (Temodal) work in treating small-cell lung cancer that has come back, is resistant to treatment or has spread through the body. The main outcome that will be measured is how well the patients respond to the treatment. The study is taking place in the United...
Read MoreIs the biosimilar drug ABP 125 as effective as bevacizumab in patients with lung cancer?
In a nutshell This study examined how safe and effective is biosimilar ABP 215 in non-small cell lung cancer (NSCLC), compared to bevacizumab (Avastin). This study concluded that this drug is as safe and effective as bevacizumab in these patients. Some background Non-small cell lung cancer (NSCLC) is the most common type of lung...
Read MoreRe-treatment with cetuximab improves cancer outcomes in patients with inoperable colorectal cancer
In a nutshell This study investigated the effect of cetuximab (Erbitux) in patients with metastatic (spread to other parts of the body) colorectal cancer who did not respond to initial cetuximab treatment. Researchers suggested that this treatment may be beneficial in longer treatment durations. Some background The standard treatment for patients...
Read MoreRectal cancer: short- and long-term outcomes of robotic assisted laparoscopic surgery
In a nutshell This article investigated the short- and long-term outcomes of patients with rectal cancer who underwent robotic-assisted laparoscopic surgery (RALS). The authors concluded that RALS is beneficial and has good short- and long-term outcomes. Some background Conventional laparoscopic surgery (CLS; involves small cuts...
Read MoreWhich treatment works best, nivolumab plus ipilimumab or nivolumab alone versus ipilimumab alone for advanced melanoma
In a nutshell This study wanted to find out which medications are better for treating advanced melanoma; nivolumab (Opdivo) plus ipilimumab (Yervoy), nivolumab alone, or ipilimumab alone. The study found that using the combination of nivolumab and ipilimumab was more effective than using nivolumab alone, with the least...
Read MoreComparing different chemotherapy combinations to improve treatment of extensive-stage small cell lung cancer
In a nutshell This study looked at a combination of irinotecan (Camptosar) and platinum-based drugs, for treating patients with extensive-stage small cell lung cancer. The authors concluded that this combination has the potential to improve the outcomes for these patients. Some background Extensive stage small-cell lung cancer (ES-SCLC) is...
Read MoreThe effect of FDG-PET imaging on patients with melanoma treated with immunotherapy.
In a nutshell The study looked at the use of FDG-PET imaging to assess long-term outcomes of treatment in patients with melanoma. Researchers found that FDG-PET imaging may be useful in predicting long-term outcomes of treatment in these patients. Some background Treatment for melanoma has vastly improved in recent years. Immunotherapies have improved...
Read MoreFulvestrant compared to aromatase inhibitors in post-menopausal women with HR+ advanced breast cancer
In a nutshell This study aimed to look at the safety and effectiveness of fulvestrant (Faslodex) compared to aromatase inhibitors in post-menopausal women with hormone receptor-positive (HR+) breast cancer. The authors found that fulvestrant was a safe and effective treatment in these patients when compared to aromatase inhibitors. Some...
Read MoreEverolimus and exemstane for treatment of HR+/HER2- advanced or metastatic breast cancer
In a nutshell This study looked at the effectiveness and safety of a combination of two cancer drugs, everolimus (Afinitor) and exemestane (Aromasin), in women after menopause with advanced breast cancer. The authors found that these drugs were safe and effective in the treatment of these women. Some background Breast cancer is...
Read MoreUsing targeted therapy to manage lung cancer disease symptoms
In a nutshell This study looked at the targeted therapy osimertinib (Targrisso) and its effectiveness at managing disease symptoms in patients with lung cancer. The study concluded that osimertinib was more effective than chemotherapy at improving disease symptoms in these patients. Some background New anti-cancer drugs target specific genetic...
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