In a nutshell This review compared the efficacy and risks associated with adding oxaliplatin (OX) to fluoropyimidine (FU) chemoradiotherapy (CRT) before surgery in patients with locally advanced rectal cancer (LARC). Some background In LARC, the cancer has grown from the rectum (the lowest part of the large bowel) into surrounding...
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Phase III clinical trial evaluating survival benefits of sequential versus concurrent docetaxel in doxorubicin-based chemotherapy in node-positive breast cancer patients
In a nutshell This phase III clinical trial evaluated the survival benefits after the addition of docetaxel into doxorubicin-based chemotherapy in node-positive breast cancer patients. Some background Node-positive breast cancer means that the cancer has spread to the lymph nodes near the breast such as under the arm or above the collarbone. Women...
Read MorePhase 3 clinical trial comparing intermittent hormonal therapy and continuous hormonal therapy in patients with advanced prostate cancer
In a nutshell The present study compared the effectiveness of two kinds of hormonal therapy in advanced prostate cancer (cancer that has spread beyond the prostate gland). These are intermittent hormonal therapy (IHT) and continuous androgen-deprivation therapy (ADT). In this study, IHT was similar to ADT in terms of survival, but showed better quality...
Read MoreEvaluating relapse patterns in stage III melanoma patients
In a nutshell The present article evaluated the time interval and site of relapse (return of the cancer) as well as survival rates in stage III melanoma patients who were considered cured after treatment. Some background Stage III melanoma is skin cancer that has spread to the nearby lymph nodes. Further classification (III A, III B and III...
Read MoreNew whole body treatments for advanced cutaneous cancer
In a nutshell This article published in 2013 reviews information from clinical studies which looked at new treatments for cutaneous melanoma. These include drugs that aim to stimulate the body's anti-tumor immune response, such as ipilimumab (Yervoy) and tremelimumab and those that target genetic mutations in cancer cells. Some background...
Read MoreAbiraterone shows increased survival in patients with metastatic prostate cancer
In a nutshell The present study evaluated the effect of Abiraterone acetate (AbAc) on survival and disease progression, when given to patients with metastatic prostate cancer (mPC) that is resistant to hormone therapy (castration-resistant). Some background Prostate cancer (PCa) growth is fueled by male hormones like...
Read MoreBosutinib: a new drug that increases progression free survival in patients with locally advanced or metastatic breast cancer
In a nutshell This paper presents the results of a clinical study which looked at the use of a new drug called Bosutinib (Bosulif) for the treatment of breast cancers diagnosed as being stage III or IV. In patients previously treated with chemotherapy, Bosutinib showed promising efficacy in delaying cancer progression. Some background Locally...
Read MoreRadiofrequency ablation may slow down the progression of metastatic colorectal cancer
In a nutshell This report aimed to establish if radiofrequency ablation (RFA) of liver metastases originating from colorectal cancer (CRC) provides any benefits to patients with Stage IV of the disease. Main result: RFA extends progression-free survival by 7 months. Some background RFA is a medical procedure for treating patients with small tumors...
Read MoreComparison of two surgical techniques for the treatment of pseudomyxoma peritonei
In a nutshell The present study compared the efficacy of two surgical techniques to treat pseudomyxoma peritonei (PMP): debulking and cytoreduction. Cytoreductive surgery achieved better surgical results and yielded higher 3- and 5-year survival rates, compared with debulking. Some background PMP is a rare condition caused by the production of...
Read MoreEvaluating cancer outcomes and safety of laparoscopic prostatectomy in patients with recurrent prostate cancer
In a nutshell The present study evaluated the safety, adverse effects and cancer outcomes of Salvage Robotic Assisted Laparoscopic Radical Prostatectomy (sRALP) in patients with recurrent prostate cancer. The procedure was surgically safe, yet 18% of the patients had another recurrence within 16 months of surgery. Some background...
Read MoreSafety and efficacy of radical prostatectomy for men with locally recurrent prostate cancer
In a nutshell The present review evaluated the efficacy, safety and complications of salvage radical prostatectomy in patients with locally recurrent prostate cancer, and sought for the ideal candidates for this procedure. Some background Prostate cancer (PCa) is the most common type of cancer in men. Treatment options for PCa which is confined to...
Read MoreThe association between insulin blood levels and risk of death in breast cancer patients
In a nutshell The present study evaluated the relationship between high insulin levels in the blood stream and the risk of cancer-related mortality. Its authors report that women with higher-than-normal insulin levels are at higher risk of death due to breast cancer. Some background Breast cancer has been shown to be more common in people who...
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