In a nutshell This study examined the safety and efficacy of a two-step hepatectomy combined with hepatic artery infusion chemotherapy as treatment for liver-spread colorectal cancer. Some background A common location for metastasis (spread) of colorectal cancer is the liver. Surgical removal of the liver tumor (hepatectomy) can increase survival...
Read MoreCurrent disease status-Recurrent cancer-Metastatic recurrence Posts on Medivizor
More risk with regorafenib
In a nutshell This study examined whether there is an increased risk of hypertension among cancer patients being treated with regorafenib (Stivarga). Some background Vascular endothelial growth factor receptors (VEGF-r) are complexes on the surface of cells which stimulate the growth of new blood vessels, and are crucial for cancer growth and...
Read MoreSkin reactions due to melanoma treatments
In a nutshell This review explored the skin toxicities associated with treatments for patients with metastatic melanoma caused by BRAF mutations. Some background Melanoma is a form of skin cancer that begins in the melanocytes, the cells that produce skin color. In metastatic melanoma, the cancer has spread to other areas of the body. Patients...
Read MoreWhat is the role of conversion chemotherapy?
In a nutshell This study assessed the survival rates and characteristics of metastatic colorectal cancer (CRC) patients with liver-limited disease (LLD) who underwent conversion chemotherapy. Some background Colorectal cancer patients may develop metastases (spread of the cancer to other distant organs and tissues of the body) and the liver is one...
Read MoreCurrent and future targeted treatments
In a nutshell This article reviewed the current standard of care in the treatment of metastatic breast cancer, as well as recent therapy advances and possible future directions. Some background Breast cancer is the most common form of female cancer. Recent knowledge of the different molecular activities within different types of breast cancer has...
Read MoreNew and current second-line treatments
In a nutshell This review discusses current second-line treatment options for metastatic colorectal cancer, as well as new advances in colorectal cancer therapy. Some background Colorectal cancer (CRC) is the third most common cancer in the world, and up to 40% of CRC patients will experience metastasis, or spread, of the disease. Advances in...
Read MoreDoes removal of the primary tumor improve survival in stage IV breast cancer?
In a nutshell This analysis of several case studies evaluated whether removal of primary tumor in stage IV breast cancer helps improve overall survival. Some background In stage IV (metastatic) breast cancer, the cancer spreads beyond the breast and nearby lymph nodes, to other organs and tissues of the body, such as the lungs, liver, bones or...
Read MoreLiver transplantation is a feasible treatment for inoperable liver metastasis in colorectal cancer patients
In a nutshell In this study, researchers examined the long term survival of patients with colorectal cancer (CRC) liver metastasis after liver transplantation. Some background Many CRC patients develop metastasis (spread of the cancer to other organs) after first diagnosis. Liver metastasis is common, and is often considered inoperable or...
Read MoreMolecular screening and targeted therapies in the treatment of metastatic melanoma
In a nutshell This study presented the results of targeted therapies in patients treated for metastatic melanoma. Some background In recent years, a growing understanding of the molecular mechanisms leading to the development of cancer has uncovered several genetic mutations associated with the formation of melanoma. New therapies which...
Read MoreObesity does not influence outcomes in patients treated for appendix and colon cancer that has spread to the abdominal cavity
In a nutshell This study evaluated whether obesity has any influence on survival in patients with peritoneal surface disease from colon or appendix cancers undergoing hyperthermic intraperitoneal chemotherapy after cytoreductive surgery. Some background Peritoneal surface disease (PSD) is a condition where cancer has spread to many spots on the...
Read MoreChemotherapy combinations in the treatment of patients with extensive small-cell lung cancer
In a nutshell This phase III study compared the benefit of three chemotherapy combinations as first line treatment (the first choice of treatment) for extensive disease small-cell lung cancer (ED-SCLC) patients. Topotecan–cisplatin (TP) combination treatment, topotecan–etoposide (TE) combination treatment, and cisplatin-etoposide (PE)...
Read MoreA new radiotherapy drug for patients with prostate cancer that has spread to the bone
In a nutshell This phase 3 clinical trial assessed the efficacy and safety of radium-223 dichloride or radium-223 (Xofigo) in patients with prostate cancer that has spread to the bone. Some background Testosterone, the main male sex hormone, promotes the growth of prostate cancer. A treatment option for prostate cancer patients is castration...
Read More
