In a nutshell This review evaluated first-line treatments for metastatic castration-resistant prostate cancer (mCRPC). Authors recommend chemotherapy with docetaxel (Taxotere) for mCRPC with high tumor burden or at high risk of rapid progression. Alternative hormonal therapy or chemotherapy may be effective in other cases. Some background...
Read MoreIn a nutshell The authors examined the long-term outcome of vaccine-treated melanoma patients. They found that vaccination was associated with better survival. Some background In advanced melanoma (stages 3 or 4) cancer spreads from the skin to other parts of the body. Cancer vaccines are a new treatment option for these stages of melanoma....
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In a nutshell This review examined the effects of different radiopharmaceuticals in reducing bone pain in advanced prostate cancer. Researchers concluded that radiopharmaceuticals were associated with a significant reduction in bone pain. Some background When prostate cancer spreads outside of the prostate (also called metastatic prostate cancer),...
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In a nutshell The authors evaluated the effectiveness of the combination treatment of AdCD40L (a gene therapy and chemotherapy) in advanced melanoma. The authors found out that the gene therapy was well tolerated with beneficial treatment outcome. Some background In advanced melanoma (stage 3 or 4), the cancer spreads from the skin to...
Read MoreIn a nutshell The authors aimed to determine the effectiveness of enzalutamide (Xtandi ) in metastatic (cancer that has spread) hormone-resistant prostate cancer compared to the standard bicalutamide (Casodex) treatment. Some background Hormone deprivation therapy is a common treatment used in prostate cancer. It targets the...
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In a nutshell The authors analyzed the outcome of a type of radiation therapy for the treatment of melanoma spread to the brain. The authors found out that the treatment was effective and well-tolerated, especially in patients with low numbers of tumors in brain and whose tumors were on the outside of the brain (extracerebral). Some background...
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In a nutshell The authors aimed to determine if palbociclib (Ibrance) could help treat women with metastatic (spread to other areas of the body) breast cancer. The researchers concluded that palbociclib showed good response rates from women with metastatic breast cancer whose cells expressed a protein called retinoblastoma (Rb). Some background...
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In a nutshell This study examined enzalutamide (Xtandi) as a treatment option for older men with metastatic castration-resistant prostate cancer. Researchers concluded that enzalutamide is well-tolerated and improves overall survival in older men with advanced prostate cancer. Some background Hormone therapy is commonly used to treat advanced...
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In a nutshell This study investigated the effects of radiation therapy in slowing disease progression in metastatic prostate cancer. Researchers concluded that radiation to the primary tumor site improves overall survival and slows the progression of metastatic prostate cancer. Some background Radiation therapy involves directing...
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In a nutshell This phase 2 study recruiting in New York aims to determine the effectiveness of regorafenib (Stivarga) in patients with metastatic colorectal cancer. The main outcome will be time to disease progression. The details The standard treatment for metastatic (spread to other areas of the body) colorectal cancer is a combination of...
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In a nutshell This study investigated whether age influenced the effectiveness and safety of radioembolization in patients with colorectal cancer which had spread to the liver. Some background There is a lack of research on treatment options for elderly colorectal cancer (CRC) patients. Elderly patients in the U.S. and Europe are 70-90%...
Read MoreIn a nutshell This study examined the efficacy of including an anti-inflammatory hormone, prednisolone (Orapred), with the chemotherapy drug docetaxel (Taxotere) in the treatment of metastatic castration-resistant prostate cancer. The study concluded that prednisolone led to a decrease in specific adverse side effects of this type of...
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