In a nutshell This study investigated the impact of liposomal doxorubicin (Adriamycin) on cardiac side effects in lymphoma patients compared to conventional doxorubicin. The study suggested that liposomal doxorubicin can reduce cardiac effects and still be an effective therapy, particularly for patients at high risk for anthracycline-induced...
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In a nutshell This study looked at the effectiveness of chemotherapy followed by a single dose of radio-immunotherapy for treating patients with mantle cell lymphoma. The study concluded that radio-immunotherapy after standard chemotherapy is safe and effective to treat patients with mantle cell lymphoma. Some background Mantle cell lymphoma (MCL)...
Read MoreIn a nutshell This study analyzed the medical records of DLBCL patients who received consolidative radiotherapy (RT) after chemotherapy to determine if consolidative RT improved survival. This study concluded that consolidative RT might improve survival in DLBCL patients. Some background Diffuse large B-cell lymphoma (DLBCL) is the most common...
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In a nutshell This study investigated the outcomes of advanced-stage classical Hodgkin’s lymphoma (HL) patients treated with ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy followed by escalated (higher dose) BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) chemotherapy...
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In a nutshell This study analyzed the outcomes of lymphoma and chronic lymphoblastic leukemia (CLL) patients who received haplo-cord stem cell transplantation. The study concluded that this method gives higher rates of engraftment and lower rates of graft-versus-host disease (GVHD) compared to haploidentical transplant. Some background High-risk...
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In a nutshell This study compared the safety and effectiveness of R-CHOP (rituximab combined with cyclophosphamide, doxorubicin, vincristine, prednisone) to CHOP-RIT (CHOP followed by iodine-133-tositumomab, Bexxar) as a first-line treatment for follicular lymphoma (FL) patients. This study concluded that immunochemotherapy should remain the standard...
Read MoreIn a nutshell This study analyzed the outcomes of older patients with stage 3 or 4 DLBCL (diffuse large B-cell lymphoma) who received biosimilar filgrastim (Neupogen) during their chemotherapy. The study concluded that filgrastim was safe and effective in these patients. Some background Diffuse large B-cell lymphoma (DLBCL) is the most common type...
Read MoreIn a nutshell This study examined the impact of multi-drug resistant organisms in patients who had undergone stem cell treatment. The study concluded that patients colonized with multi-drug resistant organisms should be watched closely for infections after transplantation. Some background Stem cell transplantation is a treatment used in...
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In a nutshell This study examined outcomes of autologous stem cell transplants after high-dose chemotherapy in non-Hodgkin lymphoma (NHL) patients with central nervous system (CNS) involvement. This study reported durable remission and good disease control for NHL with CNS involvement. Some background Many forms of NHL are treatable. When...
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In a nutshell This study examined the combination of bortezomib (Velcade), cladribine (Leustatin), and rituximab (Rituxan) for patients with mantle cell or follicular lymphoma. The authors concluded that this combination was effective and can be an alternative for patients who cannot undergo stem cell transplantation. Some background There is no...
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In a nutshell This study looked at changing treatment intensity after a PET scan for patients with advanced stage Hodgkin lymphoma. The authors concluded that reducing treatment intensity for patients with a negative PET scan can reduce negative side effects and improve long-term outcomes. Some background Advanced stage Hodgkin lymphoma (HL) can...
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In a nutshell This study aimed to investigate if a treatment combination including brentuximab vedotin (Adcetris) would be effective in treating patients with advanced Hodgkin’s lymphoma. This study concluded that treatment combinations with and without brentuximab vedotin were effective but one (BrECADD) was associated with fewer side...
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