In a nutshell This study compared two different transplant therapies used to treat acute myeloid leukaemia (AML), unmanipulated haploidentical stem cell treatment (Haplo-SCT) and HLA-matched unrelated donor stem cell transplantation (MUD). The study found that both options are useful in treating AML but MUD may have increased risk of graft versus host...
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In a nutshell This study compared the long-term effects of total body irradiation (TBI – powerful radiotherapy) plus cyclophosphamide (Cytoxan) with busulfan (Myleran) plus cyclophosphamide as part of the treatment for acute lymphoblastic leukemia (ALL). Researchers found that TBI is effective in younger patients and had higher overall survival...
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In a nutshell This study aimed to investigate if ponatinib is a suitable second-line treatment option for patients with chronic-phase chronic myeloid leukemia. This study concluded that ponatinib is a suitable option for these patients. Some background Ponatinib (Iclusig) is a tyrosine kinase inhibitor (TKI). TKIs work by blocking proteins...
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In a nutshell This study looked at the effect of using busulfan to delete blood cancer cells from the system before replacing them with normal cells in the treatment of leukaemia. The study found that busulfan therapy was effective in removing blood cancer cells before replacement, in the treatment of high-risk acute leukaemia. Some background Acute...
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In a nutshell This study looked at the effect of treosulfan combined with fludarabine (Fludara) and low-dose radiotherapy in the treatment of children with acute myeloid leukemia (AML). The researchers found that treosulfan combined with these therapies improved successful graft transplantation in the treatment of AML. Some background Acute myeloid...
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In a nutshell This study aimed to investigate the effect of anti-thymocyte globulin on the outcomes of allogeneic peripheral blood stem cell transplantation in patients with Philadelphia negative acute lymphoblastic leukemia. This study concluded that this group of patients benefited from the use of anti-thymocyte globulin. Some background Stem cell...
Read MoreIn a nutshell This study aimed to investigate the safety and effectiveness of ibrutinib (Imbruvica) in chronic lymphocytic leukemia. This study concluded that long-term administration of ibrutinib was well tolerated and provided effective disease control for most patients. Some background Ibrutinib is a targeted therapy that can be used for...
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In a nutshell This study examined the long-term safety and effectiveness of bendamustine (Treanda) in lymphoma and leukemia. This study concluded that bendamustine is a safe and effective therapy for these patients. Some background Bendamustine has been shown to have high effectiveness and few side effects for a wide range of lymphomas. This drug is...
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In a nutshell This study reviewed evidence on the safety and effectiveness of stopping TKI therapy in patients with chronic myeloid leukemia (CML). Authors concluded that discontinuing TKI therapy is safe and effective in many patients with deep molecular response. Some background Tyrosine kinase inhibitors (TKIs) is a first-line treatment for...
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In a nutshell This study compared side effects between two similar therapies – nilotinib (Tasigna) and dasatinib (Sprycel) – for chronic myeloid leukemia (CML). Researchers reported more serious side effects with dasatinib than with nilotinib. Some background Tyrosine kinase inhibitor (TKI) therapy is a standard first-line treatment...
Read MoreIn a nutshell This study aimed to compare myeloablative transplant and a sequential approach treatment in patients with relapsed or refractory acute myeloid leukemia. This study concluded that both treatments had similar outcomes for these patients. Some background Allogeneic hematopoietic stem cell transplantation (HSCT) is the only...
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In a nutshell This trial aims to see the effect of a blood thinning drug apixaban (Eliquis) in preventing blood clots in children with leukemia or lymphoma who are receiving chemotherapy. The main outcome to be measured is the occurrence of any clotting problems or bleeding side effects. The details Patients with cancer are more at risk...
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