In a nutshell This trial is comparing the effect of crenolanib with midostaurin (Rydapt) in the treatment of acute myeloid leukemia. The main outcome to be measured is event-free survival (EFS – survival time after treatment with cancer not coming back or getting worse). The details Acute myeloid leukemia (AML) is a cancer of the bone...
Read MoreCurrent disease status-First occurrence of the leukemia Posts on Medivizor
Is MRD related to treatment and survival in patients with chronic lymphocytic leukemia?
In a nutshell This study wanted to compare the effectiveness of chlorambucil (Leukeran) plus either obinutuzumab (Gazyva) or rituximab (Rituxan) in the treatment of frail patients with chronic lymphocytic leukemia (CLL). Researchers found that chlorambucil with obinutuzumab (G-Clb) was more effective than with rituximab (R-Clb) in these...
Read MoreSearching for patients with acute lymphoblastic leukemia to test new treatment combination
In a nutshell This trial is comparing the effectiveness of ponatinib (Iclusig) with imatinib (Gleevec) together with low-dose standard chemotherapy for the treatment of patients with acute lymphoblastic leukemia (ALL). The main outcome to be measured is minimal residual disease (low levels of cancer markers in the blood). This study will...
Read MoreThe effect of ibrutinib on white blood cell count in CLL
In a nutshell This study wanted to look at the effect of ibrutinib (Imbruvica) on white cell count (immune cells) in patients with chronic lymphocytic leukemia. Researchers found that increases in white cell count during ibrutinib treatment were normal and did not indicate poor outcomes in these patients. Some background Chronic lymphocytic leukemia...
Read MoreEvaluating the safety and effectiveness of ponatinib for CML
In a nutshell The study looked at the safety and effectiveness of ponatinib (Iclusig) in the treatment of chronic myeloid leukemia (CML). Researchers found that ponatinib was safe and effective in previously treated patients with CML. Some background Chronic myeloid leukemia is a type of cancer of the bone marrow. This can lead to abnormal immune...
Read MoreStem cell transplant for high risk acute lymphoblastic leukemia
In a nutshell This study reviewed the evidence for stem cell transplantation (SCT) in patients with acute lymphoblastic leukemia (ALL). Researchers found that SCT is an effective treatment option in patients with high risk of ALL coming back. Matched donors or siblings are the preferred stem cell donors. Some background ALL is a cancer of the bone...
Read MoreUse of specific T-cells in the treatment of ALL
In a nutshell This study looked at the use of specific T-cells to treat acute lymphoblastic leukemia. Researchers found that using these cells was effective in the treatment of these patients. Some background Acute lymphoblastic leukemia (ALL) is a type of cancer of the bone marrow. This can lead to abnormal cells in the immune system. It is often...
Read MoreCombinations of lenalidomide, fludarabine and rituximab for previously untreated chronic lymphocytic leukemia
In a nutshell This study aimed to investigate the safety and effectiveness of a combination of lenalidomide (Revlimid), fludarabine (Fludara) and rituximab (Rituxan) in patients with previously untreated chronic lymphocytic leukemia. This study concluded that this combination was effective, but the tolerability varied between...
Read MoreStem cell transplantation from the umbilical cord reduces the return of unresponsive acute leukemia
In a nutshell This study looked at the safety and effectiveness of using stem cells from the umbilical cord to reduce the return of disease in acute leukemia. Researchers found that stem cells from the umbilical cord were more effective than stem cells from other areas in the treatment of acute leukemia. Some background Refractory acute leukemia (rAL)...
Read MoreChlorambucil, rituximab and lenalidomide combination treatment for patients with chronic lymphocytic leukemia
In a nutshell This study aimed to evaluate the safety and effectiveness of combination treatment using chlorambucil, rituximab, and lenalidomide for patients with chronic lymphocytic leukemia. This study concluded that this combination followed by lenalidomide alone leads to outcomes comparable to other established combination treatments for these...
Read MoreSequential treatment for patients with chronic lymphocytic leukemia who have received bendamustine
In a nutshell This study aimed to investigate the effectiveness of obinutuzumab and venetoclax after bendamustine treatment in patients with chronic lymphocytic leukemia (CLL). This study concluded that this sequence of treatment caused no unexpected side effects. It also concluded that the outcomes were comparable to established therapies for CLL. Some...
Read MoreSerum Albumin or BMI: which better predicts outcomes in Acute Myeloblastic Leukaemia?
In a nutshell This study aimed to identify factors which better predict outcomes in Acute Myeloid Leukemia (AML). The authors concluded that serum albumin (a transport protein in the blood) was better at predicting AML outcomes and overall survival, but was unrelated to BMI. Some background Obesity can increase the risk...
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