In a nutshell This study examined the relationship between comorbidities (other medical conditions) and cancer progression during active surveillance. Researchers reported that progression is more likely among men with 2 or more comorbidities. Some background Active surveillance of prostate cancer refers to actively monitoring tumor growth...
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In a nutshell The authors aimed to assess and compare a number of surgical procedures used to treat and limit the risk of developing breast cancer. The study showed that there was no significant difference between contralateral prophylactic mastectomy (CPM) and breast-conserving treatment (BCT) on survival from breast cancer. Some background...
Read MoreIn a nutshell This phase III trial aims to evaluate if metformin (Glucophage) can delay the time to progression in men with low-risk prostate cancer. The main outcome to be investigated is disease progression based on the need for treatment or biopsy results. The trial is recruiting in several locations in Canada. The details Metformin is a drug...
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In a nutshell The authors analyzed the outcome of a type of radiation therapy for the treatment of melanoma spread to the brain. The authors found out that the treatment was effective and well-tolerated, especially in patients with low numbers of tumors in brain and whose tumors were on the outside of the brain (extracerebral). Some background...
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In a nutshell This study aimed to assess the effectiveness of the anti-cancer drug erlotinib (Tarceva) in treating advanced non-small cell lung cancer (NSCLC) with positive EGFR mutations in caucasian patients. The study concluded that erlotinib was safe and effective as first-line treatment in this type of cancer. Some background A mutation...
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In a nutshell This analysis provides recommendations on the correct use of biomarkers to guide decisions on systemic therapy for metastatic breast cancer. The article concluded that it is important that the medical community continue to carry out high-quality biomarker research for women with advanced breast cancer. Some background To help doctors...
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In a nutshell This study compared intermittent and continuous androgen deprivation therapy (ADT) in treating locally advanced prostate cancer. Researchers reported that both intermittent and continuous ADT were equally as effective and well-tolerated. Some background ADT is a type of hormone therapy that blocks male hormones (such as testosterone)...
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In a nutshell This review examined the benefit of adding docetaxel (Taxotere) or bisphosphonates to androgen deprivation therapy (ADT) in advanced prostate cancer. Authors reported a significant benefit when combining docetaxel with ADT in advanced metastatic prostate cancer. There is less evidence to suggest an advantage of bisphosphonates plus...
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In a nutshell This study examined the effectiveness of everolimus and bicalutamide in patients with castration-resistant prostate cancer. The authors concluded that the combination of these two therapies was effective, but with significant side effects. Some background Prostate cancer can be dependent on male hormones (such as testosterone)...
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In a nutshell This study investigated the efficacy of necitumumab (Portrazza) and chemotherapy combined treatment for locally advanced (spread to the lymph nodes) or metastatic (spread to other areas of the body) colorectal cancer. Researchers suggested that this combination was effective in patients who had not previously been treated, with...
Read MoreIn a nutshell This phase 3 trial aims to determine the effectiveness of different ways of performing prostate cancer surgery. The main outcomes to be investigated are surgical complications and cancer recurrence. The trial is recruiting in New Jersey and New York (USA). The details Surgery to remove the prostate (also known as radical...
Read MoreIn a nutshell This phase 3 trial aims to compare the effectiveness of stereotactic body radiotherapy with conventional radiotherapy in patients with early stage non-small-cell lung cancer (NSCLC) that cannot undergo surgery for medical reasons. The main outcome of the trial will be absence of local recurrence (whether the cancer has come back at or...
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