In a nutshell This study investigated the safety of oxaliplatin to treat colorectal cancer in elderly patients. Researchers suggested that oxaliplatin treatment is associated with neuropathy (numbness of arms or legs) in these patients. Some background Colorectal cancer is one of the most common forms of cancer among the elderly....
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In a nutshell This study aimed to compare the benefits of taking letrozole for 2.5 years versus 5 years in post-menopausal patients with early stage breast cancer. This study found no benefit of five years extended therapy with letrozole compared to 2.5 years, after an initial five years of hormone therapy. Some background Breast...
Read MoreIn a nutshell This study evaluated the effectiveness of filgrastim (Neupogen) as compared to original G-CSF treatments lenograstim and pegfilgrastim (Neulasta). The study concluded that filgrastim was as effective as original G-CSF treatments. Some background Low white blood cell counts can occur...
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In a nutshell This study aimed to evaluate the effectiveness and safety of endocrine therapy, with or without targeted therapy, for patients with advanced metastatic breast cancer. This study concluded that the use of endocrine therapy and targeted therapy is safe for use in patients over 65. Some background There are several treatment...
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In a nutshell This study aimed to evaluate active surveillance as an option in intermediate stage prostate cancer. It found that it should be based on multiple criteria, but is still a viable option. Gleason score, PSA, volume of cancer in biopsy, age, and MRI results should all play a role in making the decision. Some background Active...
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In a nutshell The authors aimed to determine whether cabazitaxel (Jevtana) was superior to docetaxel (Taxotere) in improving overall survival in patients with advanced, hormone-resistant prostate cancer who had not received previous treatment with chemotherapy. The authors concluded that cabazitaxel was not superior...
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In a nutshell This study aimed to identify rates of contralateral breast cancer (CBC) and ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS). This study found that rates of CBC were low and the risk of CBC was not associated with age, family history, presentation, year of surgery or radiation. Some background...
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In a nutshell This study set out to evaluate heart function in patients who received traustuzumab with anthracycline and taxane–based chemotherapy. This study concluded that, in patients without heart disease at baseline, adding traustuzumab to adjuvant anthracycline and taxane–based...
Read MoreIn a nutshell This study investigated the impact of the time between diagnosis and sentinel lymph node biopsy (SLNB) in melanoma outcomes. Researchers suggested that no negative effects are associated with delayed SLNB. Some background SLNB is a procedure used to detect lymph node metastasis (spread disease) in melanoma patients. The...
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In a nutshell This study investigated the effect of chemotherapy after surgery (CAS) in patients with locally advanced rectal cancer. Researchers suggested that the use of this therapy increases survival of the patients. Some background Surgery is the standard treatment for locally advanced rectal cancer patients. However, the use of CAS...
Read MoreIn a nutshell This phase 3 trial aims to compare an investigational drug to standard chemotherapy in breast cancer patients with brain metastases. The main outcome to be investigated is overall survival (time from treatment until death from any cause). Another outcome to be measured is progression free survival (time from treatment until disease...
Read MoreIn a nutshell This phase 3 trial aims to evaluate how effective pembrolizumab (Keytruda) is at treating triple negative breast cancer. The main outcome to be investigated is the invasive disease free survival. Other outcomes include the overall survival (time from treatment until death from any cause) and side effects. This trial is taking place...
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