In a nutshell This study compared two different chemotherapy treatments in metastatic colorectal cancer (mCRC; spread to other parts of the body). Researchers suggested that 24-hour infused irinotecan (Camptosar) plus oral S-1 (Teysuno) chemotherapy and bevacizumab (Avastin) is well tolerated and associated with improved outcomes. Some background...
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In a nutshell The study compared the long-term effects of moderate hypofractionated intensity-modulated radiation therapy (H-IMRT) and conventionally fractionated IMRT (C-IMRT) on outcomes in patients with localized prostate cancer (PC). The authors found that H-IMRT was similarly effective compared to C-IMRT after 10 years of therapy in such...
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In a nutshell This study examined if the addition of pembrolizumab (Keytruda) to chemotherapy with pemetrexed (Alimta) and platinum improved treatment results long-term for patients with advanced non-small-cell lung cancer (NSCLC). The authors found that patients who received pembrolizumab with chemotherapy had improved survival and...
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In a nutshell This study investigated the effect of atezolizumab (Tecentriq) with chemotherapy before surgery in non-small cell lung cancer (NSCLC). They found that this treatment before surgery was safe and effective. Some background Non-small cell lung cancer (NSCLC) is the most common form of lung cancer (LC)....
Read MoreIn a nutshell The study looked at the effects of long term androgen deprivation therapy (LT-ADT), pelvic lymph node radiotherapy (PLNRT) and prostate bed radiotherapy (PBRT) in patients with prostate cancer and high risk of recurrence after prostate surgery. They found an increase in survival without cancer worsening in these patients. Some...
Read MoreIn a nutshell This study set out to compare conventional-dose chemoradiotherapy (CRT) to reduced CRT based on 18F-FDG PET in locally advanced non-small cell lung cancer (NSCLC). The investigators found that 18F-FDG PET-based CRT improved tumor control without increasing side effects in these patients. Some background NSCLC accounts for...
Read MoreIn a nutshell This study examined if the frequency of the same dose of radiotherapy (RT) changed the effectiveness and safety of patients with localized prostate cancer (PC). The results showed that RT that was given weekly was as effective and safe as RT given every other day. Some background Radiotherapy (RT) is an effective treatment for...
Read MoreIn a nutshell This study compared if anti-PD-1 biological drugs were more effective alone or when used with other drugs to treat patients with advanced non-small cell lung cancer who had previously received treatment. The results showed that the combination of anti-PD-1 and other drugs such as chemotherapy improved patients’ survival more than...
Read MoreIn a nutshell This guideline reviewed treatment options for patients with newly diagnosed uveal melanoma. Some background The uvea is the middle layer of the eye. It is made up of the iris (the colored part of the eye), the ciliary body (a muscle in the eye), and the choroid (a layer of tissue in the back of the eye). In uveal melanoma (UM), tumors...
Read MoreIn a nutshell This paper is a document that was developed at a breast cancer conference by a number of experts in the field. It outlines suggested treatment for early-stage breast cancer. The experts concluded that patients and doctors should work together and discuss the benefit of treating early-stage breast cancer in comparison with the potential...
Read MoreIn a nutshell This study wanted to find out if surgically removing the main tumor in breast cancer which has spread throughout the body would impact the survival of the patient. The study found that removing the primary tumor resulted in a longer overall survival in patients with breast cancer that has spread. Some background A common treatment for...
Read MoreIn a nutshell This study investigated the effectiveness of pelvic radiotherapy (PRT) followed by chemotherapy and surgery in advanced rectal cancer. Researchers suggested that this combined treatment is associated with improved survival rates. Some background Rectal cancer affects 44,180 people each year in the US. Up to 80% of these people present...
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