In a nutshell This phase 1/2 trial will investigate BMS-986253, an experimental drug, in combination with nivolumab (Opdivo) to treat advanced cancer. The main outcomes will be the occurrence of side effects and tumor response. The details Advanced cancers have limited treatment options. New drugs are in development to improve patient prognosis. These...
Read MoreConfined or spread disease-Spread with distant metastasis Posts on Medivizor
Regorafenib side effects: how can we prevent them?
In a nutshell This article reviewed the most common side effects of regorafenib (Stivarga) treatment for patients with metastatic (spread) colorectal cancer (mCRC). The author suggested methods to prevent these side effects to increase treatment adherence. Some background The standard treatment for mCRC is chemotherapy combined with...
Read MoreLooking for patients with advanced BRAF positive colorectal cancer to test an immunotherapy treatment
In a nutshell This trial is examining the effectiveness and safety of encorafenib (Braftovi), binimetinib (Mektovi) and cetuximab (Erbitux) in patients with advanced colorectal cancer. The main outcome to be measured will be tumor response to the treatment. The details Colorectal cancer is the third most common cancer worldwide. A high number of...
Read MoreHigh dose vitamin D supplementation may be associated with improved colorectal cancer outcomes
In a nutshell This study investigated if high-dose vitamin D combined with chemotherapy improves outcomes in patients with metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that high-dose vitamin D was associated with an improved chance of survival. Some background Vitamin D is associated with the intake of...
Read MoreLooking for patients with metastatic colorectal cancer to test a new treatment
In a nutshell This trial is examining the effectiveness and safety of a combined treatment with pembrolizumab (Keytruda) and binimetinib (Mektovi). The main outcome to be measured is the tumor response to the treatment. This trial is recruiting in the United States and Canada. The details Colorectal cancer is the third most common cancer in the...
Read MoreLooking for patients with advanced colorectal cancer to test a new immunotherapy combination
In a nutshell This phase 1/2 trial is examining the effectiveness of durvalumab (Imfinzi) and monalizumab to treat patients with colorectal cancer or other solid tumors. The main outcomes to be measured are tumor response to the treatment and side effects. The details Cancer is one of the leading causes of death worldwide. Chemotherapy is only of...
Read MoreLooking for patients with advanced melanoma to test a new treatment combination
In a nutshell This phase 2 trial will investigate the effectiveness and safety of ipilimumab (Yervoy) in combination with pembrolizumab (Keytruda) in patients with melanoma that has spread to the brain. The main outcome will be the clinical benefit rate and survival. The trial is recruiting in Texas, United States. The details...
Read MoreLooking for participants to test a new vaccine to treat advanced colorectal cancer
In a nutshell This trial is examining the effectiveness and toxicity of PolyPEPI1018 vaccine in the treatment of advanced colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will be conducted in Italy, and Minnesota, US. The details The standard treatment for metastatic (spread to other parts of the body)...
Read MoreLooking for participants to test a new treatment combination for advanced colorectal cancer
In a nutshell This trial is examining the effectiveness and safety of treatment with nivolumab (Opdivo) and relatlimab in patients with advanced colorectal cancer. The main outcome to be measured will be tumor response to the treatment. This trial is being conducted in Maryland, US. The details Colorectal cancer is the third most common cancer in the...
Read MoreReviewing treatment options for patients with in-transit melanoma
In a nutshell This study reviewed treatment options for patients with in-transit melanoma. This study found that using treatments targeted to a specific area of the body may improve survival for these patients. Some background In-transit melanoma (ITM) is a type of cancer that is in the process of spreading throughout the body (metastasis). It can be...
Read MoreLooking for participants with colorectal cancer and liver metastasis to test a new cancer vaccine
In a nutshell This trial is examining the effectiveness of mFOLFOX6 (oxaliplatin, leucovorin, fluorouracil) and nivolumab (Opdivo) with and without a new cancer vaccine (CV301) for patients with colorectal cancer that has spread to the liver. The main outcome will be overall survival. This trial is being conducted in California and New Jersey,...
Read MoreLooking for participants with metastatic colorectal cancer to try a new treatment combination
In a nutshell This trial is comparing the effectiveness and toxicity of ABT-165 or bevacizumab (Avastin) plus FOLFIRI (irinotecan, leucovorin, fluorouracil) chemotherapy in patients with metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured will be tumor response and survival without cancer...
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