In a nutshell This study evaluated the incidence of new primary melanomas (NPM’s) after first diagnosis of advanced melanoma. Some background Melanoma occurs when damaged skin cells multiply rapidly and form tumors. Patients diagnosed with melanoma are at an increased risk of forming new melanoma tumors (NPM's) compared to the general...
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In a nutshell This study investigated the effect of a combined therapy of aspirin and clopidogrel on circulating tumor cells in patients with metastatic breast cancer. Some background Circulating tumor cells or CTC (cancer cells that have migrated from the tumor and are circulating in the blood stream) are known to play an important role in the...
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In a nutshell This study evaluated the use of capecitabine in combination with bevacizumab (Avastin) in the treatment of unresectable metastatic colorectal cancer. Some background Current treatment of unresectable metastatic colorectal cancer (wide spread cancer that cannot be removed by surgery do to size or location) includes chemotherapy, such...
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In a nutshell This study examined the effectiveness and safety of a new chemotherapy combination including oxaliplatin, irinotecan, and S-1 for the treatment of metastatic colorectal cancer. Some background For several years, standard chemotherapy for metastatic colorectal cancer (a cancer which has spread to other organs) included a combination...
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In a nutshell This study examined whether a combination of hormonal therapy and therapeutic cancer vaccination is an effective treatment for patients with estrogen positive (ER+) metastatic breast cancer (cancer that has spread beyond the breast, to distant organs and tissues of the body). Some background Vaccines are used to prevent many diseases...
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In a nutshell This study investigated if the amount of blood lost during surgery to remove metastatic tumors (cancer spread to distant organs of the body) on the liver from primary colorectal cancer (CRC) could be used as an indicator of long term survival and tumor recurrence (return of the cancer). Some background The liver is a common site for...
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In a nutshell This study evaluated the associating of two specific tumor markers with the survival of recurrent metastatic breast cancer patients. Some background Tumor markers refer to molecules produced by the cancer, or in response to it. These markers are often the first to indicate the presence of a cancer, and in many cases used to monitor...
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In a nutshell This review examines the evidence regarding immunotherapy in the treatment of advanced melanoma. Some background While early detection and surgical treatments have significantly reduced mortality rates for early stage melanoma patients, survival rates for advanced melanoma patients remain relatively low. Recent advances based on...
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In a nutshell This study investigated the benefits of chemotherapy to treat inoperable (that cannot be removed through surgery) metastases from colorectal cancer (CRC). Some background When CRC is discovered early, the preferred method of treatment is surgery to remove the cancer along with some surrounding healthy tissue. Chemotherapy is often...
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In a nutshell This study investigated the long-term safety and efficacy of ipilimumab in patients with advanced melanoma. Some background Patients with advanced melanoma (cancer of the pigmented cells of the skin, called melanocytes, that has invaded beyond the skin or has spread to the lymph nodes or other organs of the body) often benefit from...
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In a nutshell In this study, researchers examined the safety of surgery for patients with metastatic melanoma who recently received treatment with ipilimumab (Yervoy). Some background Ipilimumab is a drug that uses the patients’ own immune systems to fight cancer cells. It is FDA-approved for the treatment of patients with metastatic...
Read MoreIn a nutshell In this study, researchers examined the long term survival of patients with colorectal cancer (CRC) liver metastasis after liver transplantation. Some background Many CRC patients develop metastasis (spread of the cancer to other organs) after first diagnosis. Liver metastasis is common, and is often considered inoperable or...
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