In a nutshell The authors aimed to assess whether adding pertuzumab (Perjeta) to chemotherapy could improve response in women with metastatic (has spread) breast cancer. This study showed that adding pertuzumab to chemotherapy resulted in higher response rates among women with breast cancer that relied on the human epidermal growth factor 2 (HER2) to...
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In a nutshell This study compared weak opioids and low-dose morphine in providing pain relief for moderate cancer pain. Researchers concluded that low-dose morphine is more suitable as pain management for moderate cancer pain than weaker pain relievers. Some background The guidelines for cancer pain relief developed by the World Health...
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In a nutshell This study compared weak opioids and low-dose morphine in providing pain relief for moderate cancer pain. Researchers concluded that low-dose morphine is more suitable as pain management for moderate cancer pain than weaker pain relievers. Some background The guidelines for cancer pain relief developed by the World Health...
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In a nutshell The authors evaluated the safety and effectiveness of nab-paclitaxel (Abraxene), a chemotherapy, in patients with advanced melanoma. The authors found that nab-paclitaxel was safe, effective, and provided favorable outcomes. Some background In advanced melanoma, cancer spreads from the skin to other parts of the body. This is called...
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In a nutshell This study investigated whether the levels of certain proteins could be used to predict response to treatment with bevacizumab or chemotherapy in patients with colorectal cancer which has spread beyond the original tumor site. Three proteins were identified as potential biomarkers. Some background In as much as 50% of patients...
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In a nutshell This study investigated which types of immune cells are more active in fighting colorectal cancer which has spread to the liver. It was found that T cells are the most active. Some background It is thought that the immune system response to colorectal cancer (CRC) is an important factor in determining whether the disease progresses...
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In a nutshell This study investigated whether retreatment with cetuximab (Erbitux) was effective in patients whose cancer had progressed after treatment with cetuximab or panitumumab (Vectibix). The results showed that retreatment was effective in patients who had responded to previous treatment. Some background Colorectal cancer progresses...
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In a nutshell This study investigated whether age influenced the effectiveness and safety of radioembolization in patients with colorectal cancer which had spread to the liver. Some background There is a lack of research on treatment options for elderly colorectal cancer (CRC) patients. Elderly patients in the U.S. and Europe are 70-90%...
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In a nutshell This study examined the effectiveness of palbociclib (Ibrance) in the treatment of hormone receptor-positive breast cancer patients. The authors found that palbociclib treatment increased progression free survival. Some background Major treatment options for hormone receptor-positive (HR+, dependent on the hormones estrogen and/or...
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In a nutshell This study compared the efficacy and safety of two drug regimens in patients with advanced colorectal cancer. Some background Cetuxima (Erbitux) prolongs survival of patients with metastatic (spread beyond the original location of the tumor) colorectal cancer. The effects of cetuximab in combination with chemotherapy regimens that...
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In a nutshell The authors aimed to evaluate the benefit of reducing the dosage of bisphosphonate therapy (such as Fosamax or Reclast) for women with bone metastasis (the original cancer has spread to the bones). Some background Bisphosphonate therapy is a treatment used to prevent the loss of bone mass. Women who have developed bone...
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In a nutshell The authors reviewed different treatment options available for melanoma patients with cancer spread to the liver. Some background In advanced melanoma (stages 3 and 4), cancer has spreads from the skin to other parts of the body. This is known as metastasis. Treatment of liver metastasis in advanced melanoma still remains a...
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