In a nutshell This study investigated the clinical factors that influence patient response to trastuzumab (Herceptin) therapy in human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer (MBC). Hormone receptor (HR) status was found to be a possible predictor of a strong response to trastuzumab-based therapy. Some background...
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In a nutshell This study investigated whether neutropenia (NTP; loss of white blood cells) is related to improved survival in colorectal cancer patients treated with TAS-102. Researchers suggested that patients who experience NTP after one month of treatment have an improved overall survival. Some background Chemotherapy is used to treat...
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In a nutshell This study investigated the clinical features and outcomes of brain metastases in melanoma (MBM). Researchers reported that to improve outcomes for melanoma patients with brain metastasis, both clinical and pre-clinical efforts are necessary. This will include studying the brain tumor environment and associated treatment toxicities. Some...
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In a nutshell This study investigated the effect of panitumumab (Vectibix) in overall survival of patients with metastatic colorectal cancer without a KRAS or RAS mutation. Researchers suggested that panitumumab significantly improved survival in these patients. Some background Panitumumab is a therapy that targets a...
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In a nutshell This study developed guidelines for the early detection and treatment of hypophysitis (HP; inflammation of the pituitary gland), a side effect of treatment with ipilimumab. Researchers suggested that these guidelines are necessary to ensure early detection and treatment of this condition to prevent associated mortality. Some background...
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In a nutshell This study compared the effectiveness of the chemotherapy FOLFIRI plus cetuximab (Erbitux) and FOLFIRI plus bevacizumab (Avastin). Researchers suggested that FOLFIRI plus cetuximab is associated with a higher effectiveness in treating metastatic (spread to other parts of the body) colorectal cancers. Some background FOLFIRI is...
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In a nutshell This study investigated the effect of nivolumab (Opdivo) combined with ipilimumab (Yervoy) in overall survival in the treatment of advanced melanoma. Researchers suggested that this combination is associated with an improved survival when compared to ipilimumab alone. Some background Advanced melanoma is associated with...
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In a nutshell In this report, the European Society for Medical Oncology (ESMO) updated recommendations for treating metastatic (spread to other organs) colorectal cancer. Some background Colorectal cancer is one of the most common cancers diagnosed in Europe. Over the last decade in particular, the clinical outcome for patients with metastatic...
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In a nutshell This study investigated whether paclitaxel (Taxol) alone, or paclitaxel combined with bevacizumab (Avastin), had better outcomes in treating metastatic breast cancer. The authors found that paclitaxel with bevacizumab combination resulted in much better overall survival times (time from treatment until death from any cause)...
Read MoreIn a nutshell This review compared the effectiveness of talimogene laherparepvec (Imlygic) with ipilimumab (Yervoy) and vemurafenib (Zelboraf) in the treatment of metastatic (spread to other organs) melanoma. Researchers concluded that talimogene laherparepvec overall survival is at least as good as with ipilimumab and vemurafenib. Some background...
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In a nutshell This study compared the effectiveness of the chemotherapy mFOLFOX6 combined with tivozanib (Tivopath) or bevacizumab (Avastin) in metastatic colorectal cancer. Researchers suggested that these two treatments are equally effective. Some background Roughly 20% of colorectal cancer patients have metastasis (spread to other parts of...
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In a nutshell This study investigated whether the neutrophil-lymphocyte (NLR; types of white blood cells) ratio is an effective predictor of ipilimumab (Yervoy) response in metastatic (spread to other parts of the body) melanoma patients. Researchers suggested that the NLR is strongly associated with the outcome of patients treated with...
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