In a nutshell This study reviewed the currently available treatments for melanoma brain metastasis (MBM; spread to the brain). Researchers reported that treatment should be personalized for the different types of patients. Some background Melanoma has the highest risk of spreading to the brain among all common cancer types. Until the last...
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In a nutshell This study investigated the effect of nivolumab (Opdivo) in patients with progressive melanoma after ipilimumab (Yervoy) treatment. Researchers suggested that nivolumab treatment is associated with better response compared with chemotherapy. Some background Recent new therapies, such as immunotherapy, have changed the treatment of...
Read MoreIn a nutshell The study examined if age played a role in the effect of immunotherapy treatment on patients with melanoma. The study concluded that immunotherapy is similarly effective in patients of all ages. Some background Immunotherapy is a type of treatment which targets the immune system to help it to fight cancer. A specific type of...
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In a nutshell This study investigated the safety and effectiveness of capecitabine (Xeloda) as treatment for advanced colorectal cancer in patients 75 or more years old. Researchers suggested that this drug was effective in patients aged 75 or older with colorectal cancer, with manageable side effects. Some background Chemotherapy has...
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In a nutshell This study aimed to compare fulvestrant (Faslodex) to other standard endocrine agents in patients with advanced hormone sensitive breast cancer. This study concluded that fulvestrant was as effective as the available standard endocrine agents. Some background Advanced hormone sensitive breast cancer (BC) is cancer that has...
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In a nutshell This report aimed to develop recommendations for endocrine therapy in women with hormone receptor-positive metastatic breast cancer. Some background Endocrine therapy, also known as hormone therapy (HT) is used to treat hormone receptor (HR) positive metastatic breast cancer (MBC). HR positive MBC depends on the hormones estrogen or...
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In a nutshell This study investigated the tumor response and overall survival in colorectal cancer patients treated with mFOLFOX6 and bevacizumab (Avastin) or panitumumab (Vectibix). Researchers suggested that mFOLFOX+panitumumab is associated with an improved response. Some background The standard treatment for metastatic (spread to other...
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In a nutshell The aim of this phase 1 trial is to study the effectiveness of treatment with AZD1775 combined with the chemotherapy irinotecan (Camptosar). The main outcome to be measured is the tumor response to the treatment and toxicity. The details Chemotherapy is a standard treatment to colorectal cancer. It reduces symptoms and prolongs...
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In a nutshell The aim of this phase 2 trial is to compare the effectiveness of the combined treatment with chemotherapy, avelumab (Bavencio) and the vaccine Ad-CEA in patients with metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is tumor response to the treatment. This trial will recruit in Maryland,...
Read MoreIn a nutshell This study investigated the survival outcomes of surgery in melanoma patients with metastasis in the abdominal organs (AV; spread to others internal organs such as liver, stomach etc). Researchers suggested that surgery is an important treatment option for these patients. Some background Surgery is an important treatment option...
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In a nutshell This study investigated the effectiveness of the chemotherapy FOLFOX plus cetuximab (Erbitux), after cancer progression with FOLFIRI plus cetuximab. Researchers suggested that FOLFOX plus cetuximab is an important treatment option in non-KRAS mutated metastatic (spread to other parts of the body) colorectal cancer. Some background...
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In a nutshell This study investigated whether metronomic chemotherapy with oral vinorelbine (Navelbine) and capecitabine (Xeloda) was effective in treating patients with advanced HER2-negative breast cancer (BC). This form of treatment was found to be safe and effective for this patients group. Some background Metronomic chemotherapy is a form of...
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