In a nutshell This phase 2 trial is investigating the effectiveness of a treatment combination to treat metastatic (spread to other parts of the body) colorectal cancer that has not responded to prior therapy. The main outcome to be measured is response to treatment on imaging. This trial is taking place in Colorado, United...
Read MoreConfined or spread disease-Spread with distant metastasis Posts on Medivizor
Looking for patients with metastatic colorectal cancer to test a combined treatment
In a nutshell This phase 3 trial is examining the effectiveness of a combination treatment with panitumumab (Vectibix), leucovorin and fluorouracil after chemotherapy combined with panitumumab in metastatic (spread to other parts of the body) colorectal cancer. The main outcome to be measured is progression-free survival (PFS; time from treatment to...
Read MoreTreating BRCA1/2 mutated breast cancer that has spread with lurbinectedin
In a nutshell This study wanted to find out how well lurbinectedin (PM01183) works in treatment of breast cancer with BRCA1/2 mutations (abnormal genes), which has spread. The study found that lurbinectedin worked well in treating patients with BRCA1/2 mutated breast cancer which had spread. Some background BRCA1 and BRCA2 are genes that stop tumors...
Read MoreTreating BRCA1/2 mutated breast cancer that has spread with lurbinectedin
In a nutshell This study wanted to find out how well lurbinectedin (PM01183) works in treatment of breast cancer with BRCA1/2 mutations (abnormal genes), which has spread. The study found that lurbinectedin worked well in treating patients with BRCA1/2 mutated breast cancer which had spread. Some background BRCA1 and BRCA2 are genes that stop tumors...
Read MoreThyroid hormones ratio can predict outcomes in patients with advanced colorectal cancer
In a nutshell This study investigated the impact of the thyroid hormones (TH) on survival outcomes of patients with colorectal cancer treated with regorafenib (Stivarga). Researchers suggested that TH ratio can predict the outcomes in these patients. Some background TH such as FT3 (free triiodothyronine) and FT4 (free thyroxine) are released...
Read MorePredictive factors for the treatment of metastatic colorectal cancer with panitumumab
In a nutshell This study investigated the effectiveness of panitumumab (Vectibix) and the predictive factors for the treatment of metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that this treatment was effective for these patients and that early tumor shrinkage and RAS mutation (permanent change) are...
Read MoreFotemustine and temozolomide in treating advanced metastatic melanoma
In a nutshell This study wanted to find out how well two chemotherapy drugs, fotemustine (Muphoran) and temozolomide (Temodar) work in treating melanoma that had spread to other organs (metastatic melanoma). The study found that some of the patients responded to this combination of medications. Some background Metastatic melanoma can often be...
Read MoreIs regorafenib a safe option for the treatment of metastatic colorectal cancer?
In a nutshell This study investigated the effectiveness and safety of regorafenib (Stivarga) to treat patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC) that progressed after initial treatment. Researchers suggested that regorafenib is a safe option to treat these patients. Some background The standard treatment...
Read MoreAtezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.
In a nutshell This study wanted to see how well two medications worked in treating advanced triple negative breast cancer, atezolizumab (Tecentriq) and nab-paclitaxcel (Abraxane). The study found that using these two medications together improved survival in these patients. Some background Triple-negative breast cancer (TNBC) is breast cancer...
Read MoreMetronomic chemotherapy for HR+ advanced breast cancer
In a nutshell This study wanted to see how well using metronomic chemotherapy with capecitabine (Xeloda) combined with aromatase inhibitors works for patients with hormone receptor positive advanced breast cancer. The study found that this treatment works well and is safe, and therefore should be considered as a potential treatment option. Some...
Read MoreTVEC as a treatment for advanced melanoma
In a nutshell This study analysed a treatment for late-stage melanoma called talimogene laherparepvec (TVEC). It found that treating late-stage melanoma with TVEC was effective, and had only minor side effects. Some background Talimogene laherparepvec (TVEC) (Imlygic) is a treatment used for late-stage melanoma which is unable to be operated on. TVEC...
Read MoreSurgery to remove the main tumor in patients with breast cancer that has spread
In a nutshell This study wanted to find out if removing the main tumor in women with cancer that has spread to other organs leads to greater survival than not removing the main tumor. The study found that the patients who had the surgery survived 47% longer than patients without the surgery. Some background Breast cancer can sometimes be caught quite...
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