In a nutshell This trial aims to find out if a new vaccine called NEO-PV-01 is safe to use in the treatment of advanced melanoma in combination with ipilimumab (Yervoy) or APX005M and with nivolumab (Opdivo). The main outcomes that will be measured will be side effects and response to treatment. The study is being conducted in the United...
Read MoreConfined or spread disease-Spread with distant metastasis Posts on Medivizor
Looking for participants to test the effectiveness and safety of vicriviroc in the treatment of advanced colorectal cancer
In a nutshell This trial is examining the effectiveness and safety of vicriviroc (VIC) plus pembrolizumab (Keytruda) in the treatment of advanced colorectal cancer. The main outcome to be measured is the tumor response to treatment. This trial is being conducted in the US and Canada. The details Colorectal cancer is the third most common...
Read MoreOlaparib for treating breast cancer that has spread
In a nutshell This study determined whether treating breast cancer that has spread (metastatic) with olaparib (Lynparza) resulted in better outcomes and fewer side effects compared to chemotherapy. The study found that treatment with olaparib led to similar survival outcomes compared to chemotherapy. Some background There are...
Read MoreLooking for participants with advanced colorectal cancer to test a new cancer vaccine
In a nutshell This trial is examining the effectiveness of a new cancer vaccine. The main outcomes to be measured are cancer response and side effects. This trial is recruiting in New York and Tennessee, US. The details The standard treatment for most cancers is surgery and chemotherapy. However, chemotherapy has a limited effectiveness and a high...
Read MoreSearching for women with advanced breast cancer to trial a new medication
In a nutshell This trial aims to investigate a new cancer medicine called xentuzumab together with exemestane (Aromasin) and everolimus (Afinitor) in women who have breast cancer that has spread. The main outcome that will be measured is how long the patients go without cancer growing. The details Xentuzumab is a new medication that works...
Read MoreSearching for patients with untreated advanced melanoma to trial a new personalized cancer vaccine
In a nutshell This trial aims to see if combining two medications, pembrolizumab (Keytruda) and RO7198457 (a new experimental vaccine) is better than just using pembrolizumab in treating advanced melanoma that has not been treated before. The main outcome that will be measured is how long the patients go without cancer growing. The study is being...
Read MoreSearching for patients with HER2 positive breast cancer that has spread to trial a new treatment
In a nutshell This trial aims to see if combining two medications, T-DM1 (Kadcycla) and palbociclib (Ibrance) is better than just using T-DM1 in treating HER2+ breast cancer that has spread. The main outcome that will be measured is survival without the cancer growing or spreading. The study is being conducted in Arizona, the United States. The...
Read MoreCan CEA levels predict tumor response to treatment in advanced colorectal cancer?
In a nutshell This study investigated the relationship between changes in the levels of carcinoembryonic antigen (CEA) and colorectal cancer response to treatment. Researchers suggested that CEA levels are associated with tumor response and can be used as a prognostic factor. Some background In 2014 the European Society for Medical Oncology...
Read MoreLooking for patients with advanced colorectal cancer to a test two different treatment combinations
In a nutshell This phase 3 trial is examining the effectiveness of arfolitixorin versus leucovorin (folinic acid) when added to a combined treatment with 5-fluorouracil, oxaliplatin, and bevacizumab (FOB) to treat advanced colorectal cancer. The main outcome to be measured is the cancer response to the treatment. The details Treatment with...
Read MoreRegorafenib followed by cetuximab is associated with longer survival in the treatment of advanced colorectal cancer
In a nutshell This study investigated the effectiveness and safety of treatment with regorafenib (Stivarga) followed by cetuximab (Erbitux) in the treatment of advanced colorectal cancer. Researchers suggested that this treatment improves survival of these patients. Some background New treatments have become available in the past 20 years to treat...
Read MoreReal-world safety and effectiveness of BRAF inhibitors and anti-CTLA4 antibody in melanoma
In a nutshell This article investigated the safety and effectiveness of BRAF inhibitors like vemurafenib (Zelboraf) and dabrafenib (Tafinlar) and immunotherapy such as ipilimumab (Yervoy) in a real-world setting for patients with advanced melanoma. The authors concluded that this therapy is safe and...
Read MoreHypofractionated stereotactic radiotherapy improves outcomes in advanced colorectal cancer
In a nutshell This study investigated the effectiveness of hypofractionated stereotactic radiotherapy (HSR; high doses of radiation given in fewer sessions than conventional radiotherapy) in advanced colorectal cancer. Researchers suggested that HSR is associated with improved outcomes and manageable side effects. Some background Colorectal cancer is...
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