In a nutshell This study wanted to find out what the best timing is for treating patients with stage 3 melanoma with ipilimumab (Yervoy) and nivolumab (Opdivo). The study found that the best timing was two cycles of ipilimumab 1 mg/kg plus nivolumab 3 mg/kg every three weeks. Some background Ipilimumab and nivolumab are medications used to treat...
Read MoreConfined or spread disease-Spread to regional lymph nodes Posts on Medivizor
Looking for patients with advanced triple negative breast cancer to test a new drug
In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced breast cancer and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details...
Read MoreEvaluating the safety and effectiveness of palbociclib in geriatric patients
In a nutshell This study investigated the safety and effectiveness of palbociclib (Ibrance) in geriatric patients. They found that this treatment was well-tolerated and effective in these patients. Some background Breast cancer (BC) is one of the most common cancers. There are many subtypes of BC. The most common form is hormone...
Read MoreEvaluating quality of life for survivors of melanoma after immunotherapy treatment
In a nutshell This study evaluated the quality of life for survivors of melanoma who received immunotherapy. This study found that melanoma survivors had a significantly lower quality of life compared to the general population. Some background Immune checkpoint inhibitors are a new class of anti-cancer drugs that take advantage of the...
Read MoreIsolated limb infusion in patients with growing melanoma in one limb
In a nutshell This study evaluated the long-term outcomes of isolated limb infusion in patients with melanoma. This study found that this treatment was effective and safe. Some background Patients with melanoma can develop cancer that spreads or comes back after initial treatment as many small tumors. Removing these tumors by surgery is not...
Read MoreSearching for patients with triple negative breast cancer to test a new medication
In a nutshell This phase 3 trial will investigate the safety and effectiveness of adagloxad simolenin (AGS)/OBI-821 in triple-negative breast cancer (TNBC). The main outcome will be a change in survival without invasive disease. The details Breast cancer (BC) is one of the most common cancers. BC treatment depends on the tumor type....
Read MoreSearching for patients with advanced melanoma to trial a new anti-cancer vaccine
In a nutshell This trial aims to find out if a new vaccine called NEO-PV-01 is safe to use in the treatment of advanced melanoma in combination with ipilimumab (Yervoy) or APX005M and with nivolumab (Opdivo). The main outcomes that will be measured will be side effects and response to treatment. The study is being conducted in the United...
Read MoreOlaparib for treating breast cancer that has spread
In a nutshell This study determined whether treating breast cancer that has spread (metastatic) with olaparib (Lynparza) resulted in better outcomes and fewer side effects compared to chemotherapy. The study found that treatment with olaparib led to similar survival outcomes compared to chemotherapy. Some background There are...
Read MoreSearching for women with advanced breast cancer to trial a new medication
In a nutshell This trial aims to investigate a new cancer medicine called xentuzumab together with exemestane (Aromasin) and everolimus (Afinitor) in women who have breast cancer that has spread. The main outcome that will be measured is how long the patients go without cancer growing. The details Xentuzumab is a new medication that works...
Read MoreSearching for patients with untreated advanced melanoma to trial a new personalized cancer vaccine
In a nutshell This trial aims to see if combining two medications, pembrolizumab (Keytruda) and RO7198457 (a new experimental vaccine) is better than just using pembrolizumab in treating advanced melanoma that has not been treated before. The main outcome that will be measured is how long the patients go without cancer growing. The study is being...
Read MoreAtezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer.
In a nutshell This study wanted to see how well two medications worked in treating advanced triple negative breast cancer, atezolizumab (Tecentriq) and nab-paclitaxcel (Abraxane). The study found that using these two medications together improved survival in these patients. Some background Triple-negative breast cancer (TNBC) is breast cancer...
Read MoreSurgery to remove the main tumor in patients with breast cancer that has spread
In a nutshell This study wanted to find out if removing the main tumor in women with cancer that has spread to other organs leads to greater survival than not removing the main tumor. The study found that the patients who had the surgery survived 47% longer than patients without the surgery. Some background Breast cancer can sometimes be caught quite...
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