In a nutshell This phase 1/2 trial is examining the effectiveness of treatment with GB1275 alone or in combination with immunotherapy in patients with solid tumors such as triple-negative breast cancer. The main outcome to be measured will be dose toxicity and tumor response to the treatment. This study is being conducted in Tennessee and Texas, US. The...
Read MoreConfined or spread disease-Spread to regional lymph nodes Posts on Medivizor
Looking for patients with advanced melanoma to test a combination of antibody and enzyme drugs
In a nutshell This trial is examining if adding antibody drug rituximab (Rituxan) and enzyme drug hyaluronidase human (Hycela) can increase the effectiveness of the standard treatment for melanoma. The main outcomes of this trial will be to examine the side effects experienced by patients and tumor response. This study is recruiting in...
Read MoreSearching for patients with advanced triple-negative breast cancer to test a new combination treatment
In a nutshell This phase 1b/2 trial will investigate the safety of cabozantinib (Cabometyx) with or without atezolizumab (Tecentriq) in patients with advanced solid tumors. The main outcomes will be maximum tolerated dose (MTD) and overall response rate (ORR). The details Advanced cancers have limited treatment options. Surgery may...
Read MoreCombining dabrafenib, trametinib and pembrolizumab for the treatment of BRAF-mutant melanoma
In a nutshell This study investigated the effect of combined dabrafenib (Tafinlar), trametinib (Mekinist) and pembrolizumab (Keytruda) in melanoma. They found that this combination improved survival in advanced melanoma. Some background Melanoma or skin cancer is a common cancer. Genetic mutations can lead to...
Read MoreSearching for patients with advanced melanoma to trial an immunotherapy combination
In a nutshell This trial aims to investigate adding tocilizumab (Actemra) to treatment with ipilimumab (Yervoy) and nivolumab (Opdivo) for patients with advanced melanoma. The main outcome that will be measured is how the tumor size changes. The study is being conducted in New York, United States. The details...
Read MoreTiming of treatment with ipilimumab and nivolumab in patients with stage 3 melanoma
In a nutshell This study wanted to find out what the best timing is for treating patients with stage 3 melanoma with ipilimumab (Yervoy) and nivolumab (Opdivo). The study found that the best timing was two cycles of ipilimumab 1 mg/kg plus nivolumab 3 mg/kg every three weeks. Some background Ipilimumab and nivolumab are medications used to treat...
Read MoreLooking for patients with advanced triple negative breast cancer to test a new drug
In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced breast cancer and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details...
Read MoreEvaluating the safety and effectiveness of palbociclib in geriatric patients
In a nutshell This study investigated the safety and effectiveness of palbociclib (Ibrance) in geriatric patients. They found that this treatment was well-tolerated and effective in these patients. Some background Breast cancer (BC) is one of the most common cancers. There are many subtypes of BC. The most common form is hormone...
Read MoreEvaluating quality of life for survivors of melanoma after immunotherapy treatment
In a nutshell This study evaluated the quality of life for survivors of melanoma who received immunotherapy. This study found that melanoma survivors had a significantly lower quality of life compared to the general population. Some background Immune checkpoint inhibitors are a new class of anti-cancer drugs that take advantage of the...
Read MoreIsolated limb infusion in patients with growing melanoma in one limb
In a nutshell This study evaluated the long-term outcomes of isolated limb infusion in patients with melanoma. This study found that this treatment was effective and safe. Some background Patients with melanoma can develop cancer that spreads or comes back after initial treatment as many small tumors. Removing these tumors by surgery is not...
Read MoreSearching for patients with triple negative breast cancer to test a new medication
In a nutshell This phase 3 trial will investigate the safety and effectiveness of adagloxad simolenin (AGS)/OBI-821 in triple-negative breast cancer (TNBC). The main outcome will be a change in survival without invasive disease. The details Breast cancer (BC) is one of the most common cancers. BC treatment depends on the tumor type....
Read MoreSearching for patients with advanced melanoma to trial a new anti-cancer vaccine
In a nutshell This trial aims to find out if a new vaccine called NEO-PV-01 is safe to use in the treatment of advanced melanoma in combination with ipilimumab (Yervoy) or APX005M and with nivolumab (Opdivo). The main outcomes that will be measured will be side effects and response to treatment. The study is being conducted in the United...
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