In a nutshell This study is looking for postmenopausal patients with advanced breast cancer with an ESR1 mutation to compare lasofoxifene (Fablyn) to fulvestrant (Faslodex). The main outcome measured in this trial will be the patient’s survival without tumor growth or spread. This trial is recruiting in multiple locations in the United...
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Looking for patients with diabetes to try an education program with nutritional supplements to prevent retinal disease
In a nutshell This study is evaluating the impact of an education program plus nutritional supplements on the frequency of eye disease in patients with diabetes mellitus. The main outcome to be measured will be the changes in electroretinogram results, a lab test that measures vision quality. This study is recruiting in North Carolina. The...
Read MoreSearching for patients with prostate cancer to test an experimental treatment before surgery
In a nutshell This trial is investigating the effectiveness of pembrolizumab (Keytruda) plus enzalutamide (Xtandi) in patients with prostate cancer. The primary outcome to be measured will be the absence of cancer on the prostate after it is surgically removed. This study is being conducted in Portland, OR. The details...
Read MoreEvaluating a triplet regimen for patients with relapsed or refractory MM after lenalidomide therapy
In a nutshell This study examined if PBD (pomalidomide, bortezomib, dexamethasone) was safe and effective in patients with multiple myeloma after lenalidomide (Revlimid) treatment. The authors concluded that pomalidomide improved survival without tumor growth or spread but increased side effects. Some background...
Read MoreLooking for patients with relapsed or unresponsive multiple myeloma to try allogeneic CAR-T cell therapy
In a nutshell This trial is evaluating the safety and effectiveness of allogeneic CAR-T cell therapy (ALLO-715) in patients with multiple myeloma (MM) that has come back or stopped responding to treatment. The main outcome to be measured will be the number of patients who have side effects. This trial is recruiting in Denver, CO. The details Chimeric...
Read MoreLooking for patients with poorly controlled type 2 diabetes to try the EndoBarrier System
In a nutshell This study is investigating the safety and effectiveness of the EndoBarrier system for patients with poorly controlled type 2 diabetes (T2D) and obesity. The main outcome to be measured will be the change in blood glucose levels. This trial is recruiting in multiple locations across the United States. The details Bariatric surgery is the...
Read MoreLooking for participants with chronic stroke to test a device-assisted treatment
In a nutshell This study is examining the effectiveness of a device-assisted practice of activities of daily living (ADL) to treat disability in stroke survivors. The main outcome to be measured will be the change in movement of the affected arm/hand. This study is being conducted in Illinois, US. The details A stroke happens when the blood flow to...
Read MoreSearching for patients with advanced HER2-positive breast cancer to test a treatment combination
In a nutshell This phase 2 study will investigate the effectiveness of experimental medication tucatinib and trastuzumab (Herceptin) to treat brain metastases in HER2-positive breast cancer (BC). The main outcome will be overall survival (OS). This trial is recruiting in Alabama and Texas, the US. The details...
Read MoreSearching for patients with advanced prostate cancer to test an experimental medication
In a nutshell This phase 2 study will investigate the safety and effectiveness of AZD4635 in the treatment of metastatic castration-resistant prostate cancer (mCRPC). The main outcome will be the objective response rate (ORR) and prostate-specific antigen (PSA; a marker of prostate cancer) response. This trial is recruiting in multiple...
Read MoreLooking for patients with hormone-receptor positive metastatic breast cancer to test an experimental biological drug
In a nutshell This study is examining the effectiveness of biological drug sacituzumab govitecan (IMMU-132) compared to standard treatments for patients with hormone receptor-positive metastatic breast cancer. The main outcomes that will be measured are cancer responsiveness to the drug and survival of patients without the cancer growing. This trial...
Read MoreLooking for patients with aggressive B-cell NHL to try an experimental combination treatment
In a nutshell This study is investigating how well nivolumab (Opdivo) works with DA-REPOCH chemotherapy for treating aggressive B-cell non-Hodgkin's lymphoma (NHL). The primary outcome to be measured is 2-year survival without disease progression after treatment. This study is being conducted in Columbus, OH, in the United States. The...
Read MoreLooking for patients with multiple myeloma to try a maintenance therapy combination after SCT
In a nutshell This trial will compare the effectiveness of two maintenance therapies in patients with multiple myeloma (MM) after a stem cell transplant (SCT). The main outcome to be measured will be the average time from treatment until death due to any cause. The details Maintenance therapy is commonly given after SCT to help delay...
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