In a nutshell This phase 2 trial will investigate the effect of low-dose quadruple-combination therapy (LDQT) in patients with hypertension. The main outcome will be the change in systolic blood pressure (SBP; blood pressure when the heart contracts). This study is recruiting in Illinois, US. The details Hypertension or high blood...
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Looking for patients with advanced colorectal cancer to test an experimental treatment
In a nutshell This phase 1/2 trial is examining the effectiveness of treatment with GB1275 alone or in combination with immunotherapy in patients with advanced solid tumors such as colorectal cancer. The main outcome to be measured will be dose toxicity and tumor response to the treatment. This study is being conducted in Tennessee and Texas, US. The...
Read MoreLooking for patients with advanced prostate cancer to test a new treatment
In a nutshell This phase 1/2 trial is examining the effectiveness of treatment with GB1275 alone or in combination with immunotherapy in patients with advanced solid tumors such as prostate cancer. The main outcome to be measured will be dose toxicity and tumor response to the treatment. This study is being conducted in Tennessee and Texas, US. The...
Read MoreLooking for patients with advanced triple negative breast cancer to test a new treatment
In a nutshell This phase 1/2 trial is examining the effectiveness of treatment with GB1275 alone or in combination with immunotherapy in patients with solid tumors such as triple-negative breast cancer. The main outcome to be measured will be dose toxicity and tumor response to the treatment. This study is being conducted in Tennessee and Texas, US. The...
Read MoreSearching for patients with advanced prostate cancer to test a new medication
In a nutshell This phase 2b trial will evaluate ModraDoc006 (MOD) in patients with metastatic castration-resistant prostate cancer (mCRPC). The main outcomes will be the objective response rate (ORR). This trial is recruiting at a number of locations in the US. The details Metastatic castration-resistant prostate cancer (mCRPC) is...
Read MoreLooking for patients with advanced melanoma to test a combination of antibody and enzyme drugs
In a nutshell This trial is examining if adding antibody drug rituximab (Rituxan) and enzyme drug hyaluronidase human (Hycela) can increase the effectiveness of the standard treatment for melanoma. The main outcomes of this trial will be to examine the side effects experienced by patients and tumor response. This study is recruiting in...
Read MoreLooking for patients with high-risk prostate cancer to test a combination therapy
In a nutshell This study aims to examine the effectiveness of niraparib (Zejula) combined with hormone therapy and radiotherapy to treat patients with high-risk prostate cancer. The main outcome to be measured will be how long patients remain cancer-free. This study is recruiting in Philadelphia, PA. The details Prostate cancer occurs mostly...
Read MoreLooking for patients with prostate cancer to test a combination of radiotherapy
In a nutshell This phase 2 trial will investigate the effectiveness of stereotactic ablative radiation therapy (SABR) and radiopharmaceutical therapy (RPT) in patients with oligometastatic (cancer spread in 1-2 other tissues or organs) prostate cancer. The main outcome will be progression-free survival (PFS). This trial is recruiting in Maryland,...
Read MoreSearching patients with breast cancer to test EndoPredict
In a nutshell This trial will evaluate a molecular test, EndoPredict®, in the treatment of breast cancer. The main outcome will be the adherence rate to EndoPredict® results. This trial is recruiting in South Carolina, USA. It is sponsored by Myriad Genetic Laboratories. The details Adjuvant chemotherapy (ACT) is...
Read MoreLooking for patients with type 1 diabetes to compare two insulin types in an automated insulin pump
In a nutshell This study is comparing the effectiveness of two types of insulin when they are given using an automated insulin pump to patients with type 1 diabetes (T1D). The main outcome will be to examine patients’ blood glucose levels after 6 weeks. This study is recruiting in Austin, TX, US. The details T1D is a disease where...
Read MoreLooking for patients with Type 2 diabetes to test a new treatment dose
In a nutshell This study is comparing the effectiveness of two different doses of semaglutide (Ozempic) in patients with Type 2 diabetes (T2D). The main outcome to be measured will be the change in HbA1c (average blood glucose levels over 3 months). The details One of the goals of treatment for patients with T2D is to improve glycemic (blood...
Read MoreSearching for patients with advanced castration-resistant prostate cancer to test a new combination treatment
In a nutshell This phase 1b/2 trial will investigate the safety of cabozantinib (Cabometyx) with atezolizumab (Tecentriq) in patients with advanced solid tumors. The main outcomes will be the maximum tolerated dose (MTD) and overall response rate (ORR). The details Advanced cancers have limited treatment options. Surgery may not be possible....
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