In a nutshell This study compared the outcomes of metformin (Glucophage) versus insulin treatment in the management of gestational diabetes mellitus (GDM). The authors showed that metformin was a safe and effective alternative to insulin treatment in women with GDM. Some background GDM is a type of diabetes defined by an increase in blood sugar...
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The present article highlights the role of Glucagon excess in the pathogenesis of Insulin-dependent diabetes. Glucagon is a hormone produced by alpha-cells in the pancreas, as well as from cells in the stomach and intestine. Insulin is a well-known hormone produced by beta-cells in the pancreas, which reduces blood sugar by trafficking it into...
Read MoreIn a nutshell This study compared the safety and efficacy of Insulin glargine (Lantus) versus Sitagliptin (Januvia) in the management of type 2 diabetes mellitus (T2DM) poorly controlled by Metformin (Glucophage) alone. Main findings: insulin glargine provides better glycemic control than Sitagliptin when added to Metformin therapy. Some...
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In a nutshell This trial assessed the efficacy and safety of a new diabetes drug, Dapagliflozin (Forxiga). Results revealed that the drug helps control difficult cases of type 2 diabetes with only moderate side-effects. Some background Dapagliflozin is a drug recently approved by the European Medicines Agency for the treatment of diabetes. Its...
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In a nutshell This study compared the efficacy of two insulin types in pregnant women with type 1 diabetes mellitus (T1DM). HbA1c levels were similar with either insulin type, while the fasting plasma glucose was lower with insulin detemir (Levemir) use. Some background Due to destruction of insulin-producing cells in the pancreas, T1DM patients...
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In a nutshell The present article compares the effects of type 1 diabetes mellitus (T1DM) diagnosed before or after the onset of puberty on the occurrence of eye and kidney complications. The main findings were that patients diagnosed and treated for T1DM before puberty had a smaller risk for developing eye complications. Some background T1DM...
Read MoreThe present article summarizes some of the recent, prominent findings about type 1 diabetes (T1DM). These findings highlighted the great genetic variety of this disease, which point out that a more individualized management may be needed. T1DM involves the destruction of pancreatic β cells (cells that produce insulin, the main hormone that...
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In a nutshell The present study reviewed the current medical literature for new data on immunological applications involving stem cells for the treatment of type 1 diabetes mellitus (T1DM). Some background T1DM is an autoimmune disease caused by a destruction of the insulin-producing cells (IPC) in the pancreas. This means that the immune system,...
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