In a nutshell The study analyzed multiple clinical trials for assessing the effects of carfilzomib (Kyprolis) based treatment on kidney toxicity in patients with multiple myeloma (MM). The main finding was that kidney toxicity was an important side effect of carfilzomib based therapy. Some background Carfilzomib is largely used to treat MM. It is a...
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In a nutshell The study evaluated occurrence, risk-factor, and exercise response of cardiac autonomic dysfunction (CAD) in adult survivors of childhood acute lymphoblastic leukemia (ALL). The authors found that over one-third of survivors developed CAD. It was related to lower exercise capacity. Some background Survivors of childhood ALL have reduced...
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In a nutshell This study investigated the effectiveness of minimally invasive surgery in rectal cancer. Researchers suggested that less invasive surgery methods can result in better short-term outcomes in appropriately selected patients. Some background Colorectal cancer is the third most common cancer in the US. Rectal cancer comprises around 20% of...
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In a nutshell This study investigated the effectiveness of the combined treatment with cytokine-induced killer cell (CIKC) immunotherapy and chemotherapy after surgery in colorectal cancer. Researchers suggested that this therapy improves treatment outcomes in patients with colorectal cancer. Some background Colorectal cancer is one of the most common...
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In a nutshell This study examined the effectiveness and safety of adding brentuximab vedotin (Adcetris) to R-CHP (rituximab, cyclophosphamide, doxorubicin, and prednisone) chemotherapy for patients with non-Hodgkin lymphoma (NHL). The authors concluded that the treatment was very effective and safe for patients. Some background Chemotherapy...
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In a nutshell This study examined how effective and safe a higher radiotherapy dose was for patients with non-Hodgkin lymphoma (NHL) undergoing stem cell transplantation (SCT). The authors found that patients who received a lower radiotherapy dose survived longer and had fewer side effects than the higher dose. Some background NHL is a cancer of...
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In a nutshell This study aimed to investigate treatment options for chronic lymphocytic leukemia (CLL). This study concluded that treatment results from clinical trials may not be seen in a real-life setting and that novel agents can improve outcomes for these patients. Some background Traditional treatments for CLL include...
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In a nutshell This study looked at whether iGlarLixi (Soliqua), a combination of long-acting insulin glargine (Lantus) and lixisenatide (Lyxumia), can improve glucose control for patients with type 2 diabetes (T2D) uncontrolled with long-acting insulin alone. It found that iGlarLixi improved overall and after-meal blood sugar control compared to insulin...
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In a nutshell This study investigated the effectiveness and safety of regorafenib (Stivarga) treatment in older patients with colorectal cancer (CRC). Researchers suggested that this treatment has similar effects in younger and older patients. Some background CRC is the third most common cancer worldwide. More than half are diagnosed in patients older...
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In a nutshell This study examined the safety and effectiveness of targeted therapy abemaciclib (Verzenio) for patients with relapsed or refractory mantle cell lymphoma (MCL). The results showed that abemaciclib had promising effectiveness and was relatively safe in these patients. Some background MCL is an aggressive type of lymphoma. During...
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In a nutshell This study examined if brachytherapy, a type of radiotherapy, is more effective with or without hormonal therapy for patients with localized prostate cancer. The authors found that patients survived longer without cancer worsening after treatment with brachytherapy and hormonal therapy. Some background Brachytherapy (BT) is a type...
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In a nutshell This study examined if acupuncture is an effective treatment for patients with nerve damage caused by chemotherapy for breast cancer. The results showed that patients had improved sensory and muscle symptoms, less pain, and improved quality of life following acupuncture treatment. Some background One side effect of chemotherapy is...
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